2,2,5,5-Tetramethylpiperazine

Base Information

• Chemical Name: 2,2,5,5-Tetramethylpiperazine
• CAS No.: 5434-90-2
• Molecular Formula: C8H18 N2
• Molecular Weight: 142.244
• Hs Code.: 2933599090
• NSC Number: 15129
• DSSTox Substance ID: DTXSID40280026
• Wikidata: Q72507726
• Mol file: 5434-90-2.mol

Synonyms:2,2,5,5-tetramethylpiperazine;5434-90-2;2,2,5,5-Tetramethyl-piperazine;Piperazine,2,2,5,5-tetramethyl-;NSC15129;SCHEMBL8606512;DTXSID40280026;NSC 15129;NSC-15129;AKOS005266493;CS-0055723;A846483

Chemical Property of 2,2,5,5-Tetramethylpiperazine

Chemical Property:

• Vapor Pressure: 0.873mmHg at 25°C
• Melting Point: 85-87℃
• Boiling Point: 176-183℃
• PKA: 9.75±0.60(Predicted)
• Flash Point: 53.5°C
• PSA: 24.06000
• Density: 0.811g/cm³
• LogP: 1.39400
• Storage Temp.: 2-8°C
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 142.146998583
• Heavy Atom Count: 10
• Complexity: 111

Purity/Quality:

99% ^*data from raw suppliers

2,2,5,5-Tetramethylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CNC(CN1)(C)C)C

Technology Process of 2,2,5,5-Tetramethylpiperazine

There total 6 articles about 2,2,5,5-Tetramethylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-amino-isobutyraldehyde-oxime (70183-48-1) → 2,2,5,5-tetramethyl-piperazine (5434-90-2) + 1,1-dimethylethylenediamine (811-93-8)

Guidance literature:

With sodium amalgam; acetic acid;

DOI:10.1039/jr9340000049

Reference yield:

→ 2,2,5,5-tetramethyl-piperazine (5434-90-2) + 1,1-dimethylethylenediamine (811-93-8)

Guidance literature:

With sodium amalgam; acetic acid;

DOI:10.1039/jr9340000049

Reference yield:

→ 2,2,5,5-tetramethyl-piperazine (5434-90-2) + 1,1-dimethylethylenediamine (811-93-8)

Guidance literature:

With sodium amalgam; ethanol; acetic acid;

DOI:10.1039/jr9340000049

upstream raw materials:

3,3,6,6-tetramethyl-2,5-dioxopiperazine

(2,2,5,5-tetramethyl-piperazino)-acetic acid ethyl ester

α-amino-isobutyraldehyde-oxime

ethanol

Downstream raw materials:

2-(2,2,5,5-tetramethyl-piperazino)-ethanol

1,4-bis-(2-hydroxy-ethyl)-2,2,5,5-tetramethyl-piperazine

1,2,2,4,5,5-hexamethyl-piperazine

1,4-dibenzyl-2,2,5,5-tetramethyl-piperazine