2 4 6-TRIMETHYL-N-METHYLANILINE 97

Base Information

• Chemical Name: 2 4 6-TRIMETHYL-N-METHYLANILINE 97
• CAS No.: 13021-14-2
• Molecular Formula: C10H15N
• Molecular Weight: 149.236
• Hs Code.: 2921430090
• Mol file: 13021-14-2.mol

Synonyms:Aniline,N,2,4,6-tetramethyl- (6CI,7CI,8CI);N,2,4,6-Tetramethylbenzenamine;N-Methyl-2,4,6-trimethylaniline;N-Methylmesitylamine;

Chemical Property of 2 4 6-TRIMETHYL-N-METHYLANILINE 97

Chemical Property:

• Vapor Pressure: 0.0465mmHg at 25°C
• Refractive Index: n20/D 1.5320(lit.)
• Boiling Point: 236.8 °C at 760 mmHg
• Flash Point: 96 °C
• PSA: 12.03000
• Density: 0.946g/cm³
• LogP: 2.72650
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2,4,6-Trimethyl-N-methylaniline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi; N
• Hazard Codes: Xi,N
• Statements: 36/38-50/53
• Safety Statements: 26-60-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2 4 6-TRIMETHYL-N-METHYLANILINE 97

There total 18 articles about 2 4 6-TRIMETHYL-N-METHYLANILINE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

O-(p-toluenesulfonyl)-N-methylhydroxylamine (25370-97-2) + 1,3,5-trimethyl-benzene (108-67-8) → N-methyl-2,4,6-trimethylaniline (13021-14-2)

Guidance literature:

With air; at 20 ℃; for 36h; Reagent/catalyst; chemoselective reaction;

DOI:10.1002/adsc.202100236

Reference yield: 74.0%

N-methyl-O-((4-nitrophenyl)sulfonyl)hydroxylammonium trifluoromethanesulfonate + 1,3,5-trimethyl-benzene (108-67-8) → N-methyl-2,4,6-trimethylaniline (13021-14-2)

Guidance literature:

With ferrous(II) sulfate heptahydrate; at 40 ℃; for 16h;

DOI:10.1021/acs.orglett.1c00099

Reference yield: 71.0%

O-mesitylenesulfonyl-N-tert-butoxycarbonyl-N-methylhydroxylamine (65962-97-2) + 1,3,5-trimethyl-benzene (108-67-8) → N-methyl-2,4,6-trimethylaniline (13021-14-2)

Guidance literature:

With 1,10-Phenanthroline; copper(II) bis(trifluoromethanesulfonate); at 60 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00586

upstream raw materials:

2,4,6,N-tetramethyl-N-nitroso-aniline

2-isocyanato-1,3,5-trimethylbenzene

dimethyl sulfate

2,4,6-trimethylaniline

Downstream raw materials:

bis-[(2,4,6,N-tetramethyl-anilino)-methyl]-peroxide

3-bromo-N,2,4,6–tetramethyl aniline

2-(Formyl-methylamino)-1,3,5-trimethylbenzol

N-Methyl-N-(2,4,6-trimethyl-phenyl)-propionamide

Refernces

• 1、 Wang, Tao,Hoffmann, Marvin,Dreuw, Andreas,Hasagi?, Edina,Hu, Chao,Stein, Philipp M.,Witzel, Sina,Shi, Hongwei,Yang, Yangyang,Rudolph, Matthias,Stuck, Fabian,Rominger, Frank,Kerscher, Marion,Comba, Peter,Hashmi, A. Stephen K.. "A Metal-Free Direct Arene C?H Amination". supporting information. p. 2783 - 2795. Retrieved 2021/04/05.
• 2、 Chippindale, Ann M.,Gavriel, Alexander G.,Hayes, Wayne,Khurana, Gurjeet S.,Leroux, Flavien,Lewis, Viliyana G.,Russell, Andrew T.,Sambrook, Mark R.. "Self-Immolative System for Disclosure of Reactive Electrophilic Alkylating Agents: Understanding the Role of the Reporter Group". . p. 10263 - 10279. Retrieved 2021/08/16.