2-Phenylpyrazolo[5,1-a]isoquinoline

Base Information

• Chemical Name: 2-Phenylpyrazolo[5,1-a]isoquinoline
• CAS No.: 61001-36-3
• Molecular Formula: C17H12N2
• Molecular Weight: 244.296
• Hs Code.: 2933990090
• Mol file: 61001-36-3.mol

Synonyms:2-phenyl-pyrazolo<5,1-a>isochinolin;Pyrazolo(5,1-a)isoquinoline,2-phenyl;2-Phenylpyrazolo(5,1-a)isoquinoline;2-phenylpyrazolo[1,5-a]isoquinoline;

Chemical Property of 2-Phenylpyrazolo[5,1-a]isoquinoline

Chemical Property:

• Refractive Index: 1.5794 (estimate)
• Boiling Point: 377.21°C (rough estimate)
• PSA: 17.30000
• Density: 1.17g/cm³
• LogP: 4.15450

Purity/Quality:

99% ^*data from raw suppliers

2-PHENYLPYRAZOLO-[5,1-A]ISOQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Phenylpyrazolo[5,1-a]isoquinoline

There total 23 articles about 2-Phenylpyrazolo[5,1-a]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-(2-bromophenyl)-5-phenyl-1H-pyrazole (1387637-91-3) + tris-iso-propylsilyl acetylene (89343-06-6) → 2-phenyl-pyrazolo<5,1-a>isoquinoline (61001-36-3)

Guidance literature:

With potassium carbonate; copper(I) bromide; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 30h; Inert atmosphere; Sealed tube;

DOI:10.1039/c3ra40270c

Reference yield: 90.0%

2-ethynylbenzaldehyde tosylhydrazone (343232-24-6) + phenylacetylene (536-74-3) → 2-phenyl-pyrazolo<5,1-a>isoquinoline (61001-36-3)

Guidance literature:

With copper(l) iodide; (1,3-dimesityl-5-methyl-6-oxo-6H-pyrimidin-2-ylidene-4-olate)-copper(I) lithium(THF)2; potassium tert-butylate; toluene-4-sulfonic acid hydrazide; In 1,4-dioxane; at 90 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tet.2017.09.037

Reference yield: 88.0%

N'-(2-((trimethylsilyl)ethynyl)-benzylidene)-4-methylbenzenesulfonohydrazide (1361106-96-8) + phenylacetylene (536-74-3) → 2-phenyl-pyrazolo<5,1-a>isoquinoline (61001-36-3)

Guidance literature:

With copper(l) iodide; C₈H₁₆LiO₂⁽¹⁺⁾*C₂₉H₃₇ClCuN₂O₂^(1-); potassium tert-butylate; toluene-4-sulfonic acid hydrazide; In 1,4-dioxane; at 90 ℃; for 4h; Reagent/catalyst; Solvent; Catalytic behavior; Inert atmosphere;

DOI:10.1016/j.tet.2017.09.037

upstream raw materials:

syn-(E)-2-(1-Isochinolyl)-1-phenylethanonoxim

2,4,6-Trimethyl-benzenesulfonate2-amino-1-phenylethynyl-isoquinolinium;

2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline

2-phenyl-pyrazolo[5,1-a]isoquinoline-1-carboxylic acid ethyl ester

Refernces

• 1、 Ling, Lin,Chen, Jingqing,Song, Jiahui,Zhang, Yuhai,Li, Xinqian,Song, Lijuan,Shi, Feng,Li, Yuxue,Wu, Chunrui. "From N-benzoylpyridinium imides to pyrazolo[1,5-a]pyridines: A mechanistic discussion on a stoichiometric Cu protocol". supporting information. p. 3894 - 3902. Retrieved 2014/03/21.