Methyl 2-(2-broMoacetyl)benzoate

Base Information

• Chemical Name: Methyl 2-(2-broMoacetyl)benzoate
• CAS No.: 7460-55-1
• Molecular Formula: C10H9 Br O3
• Molecular Weight: 257.084
• Mol file: 7460-55-1.mol

Synonyms:Benzoicacid, 2-(bromoacetyl)-, methyl ester (9CI); Benzoic acid, o-(bromoacetyl)-,methyl ester (8CI); 2-(Bromoacetyl)benzoic acid methyl ester; Methyl2-(2-bromoacetyl)benzoate; NSC 54396

Chemical Property of Methyl 2-(2-broMoacetyl)benzoate

Chemical Property:

• Vapor Pressure: 0.000137mmHg at 25°C
• Boiling Point: 333.4°Cat760mmHg
• Flash Point: 155.4°C
• PSA: 43.37000
• Density: 1.494g/cm³
• LogP: 2.05080

Purity/Quality:

97-99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-(2-broMoacetyl)benzoate

There total 5 articles about Methyl 2-(2-broMoacetyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 2-acetylbenzoate (1077-79-8) → 2-(2-bromoacetyl)benzoic acid methyl ester (7460-55-1)

Guidance literature:

With phenyltrimethylammonium tribromide; In tetrahydrofuran; at 20 ℃; for 15h;

DOI:10.3390/11070574

Reference yield: 66.0%

C16H24O3Si → 2-(2-bromoacetyl)benzoic acid methyl ester (7460-55-1)

Guidance literature:

With N-Bromosuccinimide; In tetrahydrofuran; aq. phosphate buffer; at 0 ℃; for 1h; pH=7; Cooling with ice;

DOI:10.1021/jacs.8b13157 DOI:10.1021/jacs.8b13157

Reference yield:

2-acetyl-benzoic acid (577-56-0) → 2-(2-bromoacetyl)benzoic acid methyl ester (7460-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone / 3 h / Heating

2: 80 percent / phenyltrimethylammonium tribromide / tetrahydrofuran / 15 h / 20 °C

With phenyltrimethylammonium tribromide; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.3390/11070574

upstream raw materials:

methyl 2-acetylbenzoate

phthalic anhydride

2-acetyl-benzoic acid

Downstream raw materials:

N-benzylisoquinoline-1,3,4(2H)-trione

Refernces

• 1、 Wang, Bo,Lamattina, Joseph W.,Marshall, Savannah L.,Booker, Squire J.. "Capturing Intermediates in the Reaction Catalyzed by NosN, a Class C Radical S-Adenosylmethionine Methylase Involved in the Biosynthesis of the Nosiheptide Side-Ring System". . p. 5788 - 5797. Retrieved 2019/04/17.