2,5-Dimethylthiazole

Base Information

• Chemical Name: 2,5-Dimethylthiazole
• CAS No.: 4175-66-0
• Molecular Formula: C5H7 N S
• Molecular Weight: 113.183
• Hs Code.: 2934100090
• European Community (EC) Number: 806-489-4
• UNII: 4JGJ9O7P4J
• DSSTox Substance ID: DTXSID3063336
• Nikkaji Number: J129.804F
• Wikidata: Q27259755
• Metabolomics Workbench ID: 45824
• Mol file: 4175-66-0.mol

Synonyms:2,5-Dimethylthiazole;4175-66-0;2,5-Dimethyl-1,3-thiazole;Thiazole, 2,5-dimethyl-;2,5-dimethyl thiazole;2,5-dimethyl-thiazole;UNII-4JGJ9O7P4J;4JGJ9O7P4J;MFCD00130120;SCHEMBL119227;DTXSID3063336;FEMA NO. 4035;CHEBI:184697;BCP22024;2,5-DIMETHYLTHIAZOLE [FHFI];AKOS006275451;CS-W002408;AS-15118;SY030427;FT-0610417;FT-0610483;EN300-90249;Q27259755;2-{[4-(4-Fluorophenyl)-6-(trifluoromethyl)-pyrimidin-2-yl]thio}propanoicacid

Chemical Property of 2,5-Dimethylthiazole

Chemical Property:

• Appearance/Colour: Yellow liquid; Cooked, brown and roasted nutty aroma
• Vapor Pressure: 4.28mmHg at 25°C
• Refractive Index: 1.5605 (estimate)
• Boiling Point: 153.4 °C at 760 mmHg
• PKA: pK1:3.91 (25°C,μ=0.1)
• Flash Point: 46 °C
• PSA: 41.13000
• Density: 1.081 g/cm³
• LogP: 1.75990
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 113.02992040
• Heavy Atom Count: 7
• Complexity: 65.1

Purity/Quality:

99% ^*data from raw suppliers

2,5-Dimethylthiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(S1)C

Technology Process of 2,5-Dimethylthiazole

There total 1 articles about 2,5-Dimethylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylthiazole (3581-87-1,260998-77-4) + methyl iodide (74-88-4) → 2-ethylthiazole (15679-09-1) + 2,5-dimethyl-1,3-thiazole (4175-66-0)

Guidance literature:

Multistep reaction; (i) nBuLi, Et₂O, (ii) /BRN= 969135/;

Reference yield:

2,5-dimethyl-1,3-thiazole (4175-66-0) + benzaldehyde (100-52-7) → 5-methyl-2-trans-styryl-thiazole

Guidance literature:

With zinc(II) chloride; at 160 ℃;

DOI:10.1002/hlca.19480310421

Reference yield:

2,5-dimethyl-1,3-thiazole (4175-66-0) + α-bromoacetophenone (70-11-1) → 2,5-Dimethyl-3-phenacyl-thiazolium (1212-02-8)

Guidance literature:

In ethanol;

DOI:10.1039/jr9650000065

upstream raw materials:

2-methylthiazole

methyl iodide

Downstream raw materials:

2,5-Dimethyl-3-phenacyl-thiazolium

5-(bromomethyl)-2-methylthiazole