Technology Process of Codonocarpine
There total 11 articles about Codonocarpine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 50 percent / Cu, Et3N / methanol
2: 96 percent / pyridine, piperidine
3: oxalyl chloride
5: 90 percent / tetrahydrofuran / 336 h / Ambient temperature
6: KOH, H2O / methanol
7: dicyclohexylcarbodiimide / pyridine
8: 1.) trifluoroacetic acid; 2.) pyridine / 1.) methylene chloride, 23 deg C, 18 min; 2.) dimethylformamide, 90 deg C, 4 h, room temp., 12 h
9: trifluoroacetic acid / 10 h
With
piperidine; pyridine; potassium hydroxide; oxalyl dichloride; water; copper; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; pyridine; methanol;
DOI:10.1016/S0040-4039(00)92847-8
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 96 percent / pyridine, piperidine
2: oxalyl chloride
4: 90 percent / tetrahydrofuran / 336 h / Ambient temperature
5: KOH, H2O / methanol
6: dicyclohexylcarbodiimide / pyridine
7: 1.) trifluoroacetic acid; 2.) pyridine / 1.) methylene chloride, 23 deg C, 18 min; 2.) dimethylformamide, 90 deg C, 4 h, room temp., 12 h
8: trifluoroacetic acid / 10 h
With
piperidine; pyridine; potassium hydroxide; oxalyl dichloride; water; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; pyridine; methanol;
DOI:10.1016/S0040-4039(00)92847-8
- Guidance literature:
-
Multi-step reaction with 7 steps
1: oxalyl chloride
3: 90 percent / tetrahydrofuran / 336 h / Ambient temperature
4: KOH, H2O / methanol
5: dicyclohexylcarbodiimide / pyridine
6: 1.) trifluoroacetic acid; 2.) pyridine / 1.) methylene chloride, 23 deg C, 18 min; 2.) dimethylformamide, 90 deg C, 4 h, room temp., 12 h
7: trifluoroacetic acid / 10 h
With
pyridine; potassium hydroxide; oxalyl dichloride; water; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; pyridine; methanol;
DOI:10.1016/S0040-4039(00)92847-8