N-(4-Aminobenzoyl)-DL-glutamic acid

Base Information

• Chemical Name: N-(4-Aminobenzoyl)-DL-glutamic acid
• CAS No.: 4230-33-5
• Molecular Formula: C12H14N2O5
• Molecular Weight: 266.254
• Hs Code.: 2924299090
• Mol file: 4230-33-5.mol

Synonyms:DL-Glutamicacid, N-(4-aminobenzoyl)-;Glutamic acid, N-(p-aminobenzoyl)-, DL- (8CI);NSC267432;

Chemical Property of N-(4-Aminobenzoyl)-DL-glutamic acid

Chemical Property:

• Vapor Pressure: 1.37E-15mmHg at 25°C
• Refractive Index: 1.617
• Boiling Point: 607.1 °C at 760 mmHg
• Flash Point: 320.9 °C
• PSA: 129.72000
• Density: 1.418 g/cm³
• LogP: 1.28870

Purity/Quality:

99%, ^*data from raw suppliers

2-[(4-Aminobenzoyl)amino]pentanedioic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-Aminobenzoyl)-DL-glutamic acid

There total 5 articles about N-(4-Aminobenzoyl)-DL-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-{4-[(2-amino-4-hydroxy-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid (59-30-3) → N-(4-aminobenzoyl)-glutamic acid (4230-33-5,532-63-8) + 6-pterinaldehyde (712-30-1)

Guidance literature:

With oxygen; In water; at 20 ℃; pH=10.0 - 11.0; Product distribution; Quantum yield; Photolysis;

DOI:10.1002/1522-2675(200208)85:8<2300::AID-HLCA2300>3.0.CO;2-B

Reference yield:

p-NO2C6H4CONHCH(CH2CH2COOH)COOH (22536-03-4) → N-(4-aminobenzoyl)-glutamic acid (4230-33-5,532-63-8)

Guidance literature:

With ammonium hydroxide; iron(II) sulfate;

Reference yield:

Glutamic acid (617-65-2,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → N-(4-aminobenzoyl)-glutamic acid (4230-33-5,532-63-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH solution

2: Hydrogenation_.katalytisch

With sodium hydroxide;

upstream raw materials:

p-NO₂C₆H₄CONHCH(CH₂CH₂COOH)COOH

2-{4-[(2-amino-4-hydroxy-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid

Glutamic acid

4-nitro-benzoyl chloride

Downstream raw materials:

folate

N-{4-[(2-thioxo-benzothiazol-3-ylmethyl)-amino]-benzoyl}-glutamic acid

N-{4-[(2-thioxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-glutamic acid

N-{4-[(4-amino-2-methylsulfanyl-pteridin-6-ylmethyl)-amino]-benzoyl}-DL-glutamic acid

Refernces