2-Amino-5-bromine-2'-chloro benzophenone

Base Information

• Chemical Name: 2-Amino-5-bromine-2'-chloro benzophenone
• CAS No.: 60773-49-1
• Molecular Formula: C13H9BrClNO
• Molecular Weight: 310.578
• Hs Code.: 29223990
• Mol file: 60773-49-1.mol

Synonyms:5-Bromo-2'-chloro-2-aminobenzophenone;

Chemical Property of 2-Amino-5-bromine-2'-chloro benzophenone

Chemical Property:

• Appearance/Colour: yellow crystal powder
• Melting Point: 85-87°C
• Boiling Point: 456.2 °C at 760 mmHg
• PKA: -1.03±0.10(Predicted)
• Flash Point: 229.7 °C
• PSA: 43.09000
• Density: 1.568 g/cm³
• LogP: 4.49690
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-5-bromo-2'-chlorobenzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Phenazepam metabolite.

Technology Process of 2-Amino-5-bromine-2'-chloro benzophenone

There total 5 articles about 2-Amino-5-bromine-2'-chloro benzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-amino-5-bromobenzonitrile (39263-32-6) + 2-Chlorobenzeneboronic acid (3900-89-8) → (2-amino-5-bromophenyl)(2-chlorophenyl)methanone (60773-49-1)

Guidance literature:

With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; In 2-methyltetrahydrofuran; water; at 80 ℃; for 36h;

DOI:10.1016/j.bmcl.2020.127687

Reference yield: 37.0%

o-chlorobenzoyl chloride (609-65-4) + 4-bromo-aniline (106-40-1) → (2-amino-5-bromophenyl)(2-chlorophenyl)methanone (60773-49-1)

Guidance literature:

o-chlorobenzoyl chloride; 4-bromo-aniline; at 0 - 120 ℃; for 1h;

With zinc(II) chloride; at 120 - 195 ℃; for 3h;

With hydrogenchloride; sulfuric acid; water; more than 3 stages;

Reference yield:

3-hydroxy-7-bromo-5-(2'-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-one (70030-11-4) → (2-amino-5-bromophenyl)(2-chlorophenyl)methanone (60773-49-1)

Guidance literature:

With hydrogenchloride; for 0.5h; boiling water bath;

DOI:10.1007/BF00777451

upstream raw materials:

o-chlorobenzoyl chloride

4-bromo-aniline

3-hydroxy-7-bromo-5-(2'-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-one

phenazepam

Downstream raw materials:

5-bromo-2-(2-bromo-acetylamino)-2'-chloro-benzophenone

5-Bromo-3-(2-chloro-phenyl)-1H-indazole

4-amino-3-(2-chlorobenzoyl)benzonitrile

phenazepam

Refernces

• 1、 -. "ANXIOLYTIC AGENTS WITH REDUCED SEDATIVE AND ATAXIC EFFECTS". Page/Page column 49; 50-51. . Retrieved 2010/02/07.