N2-(1-Oxododecyl)-L-lysine

Base Information

• Chemical Name: N2-(1-Oxododecyl)-L-lysine
• CAS No.: 59409-41-5
• Molecular Formula: C18H36N2O3
• Molecular Weight: 328.495
• European Community (EC) Number: 261-742-0
• DSSTox Substance ID: DTXSID50974823
• Mol file: 59409-41-5.mol

Synonyms:N2-(1-Oxododecyl)-L-lysine;N-Lauroyl-DL-lysine;6-amino-2-(dodecanoylamino)hexanoic acid;186832-69-9;N6-Lauroyl-L-lysine;n-lauroyl lysine;EINECS 261-742-0;SCHEMBL15474;AQUALINESTANDARD10.0;DTXSID50974823;N~2~-(1-Hydroxydodecylidene)lysine;FT-0650605

Chemical Property of N2-(1-Oxododecyl)-L-lysine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.482
• Boiling Point: 526 °C at 760 mmHg
• Flash Point: 271.9 °C
• PSA: 92.42000
• Density: 0.994 g/cm³
• LogP: 4.69690
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 16
• Exact Mass: 328.27259301
• Heavy Atom Count: 23
• Complexity: 309

Purity/Quality:

99% ^*data from raw suppliers

(S)-6-Amino-2-dodecanamidohexanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCCCCCCCCC(=O)NC(CCCCN)C(=O)O

Technology Process of N2-(1-Oxododecyl)-L-lysine

There total 12 articles about N2-(1-Oxododecyl)-L-lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-2-dodecanoyl-N-6-tert-butoxycarbonyl-L-lysine (609819-28-5) → N-lauroyl-L-lysine (59409-41-5)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 5h;

Reference yield: 44.0%

lauric acid (143-07-7) + L-lysine (56-87-1,3506-25-0) → N-lauroyl-L-lysine (59409-41-5) + Nε-lauroyl-L-lysine (52315-75-0)

Guidance literature:

With Streptomyces mobaraensis NBRC 13819 acylase; In glycerol; at 37 ℃; for 48h; pH=7.5;

DOI:10.1021/jf052102k

Reference yield: 32.0%

tetrabutylphosphonium lysinate + methyl n-dodecanoate (111-82-0) → N-lauroyl-L-lysine (59409-41-5) + Nε-lauroyl-L-lysine (52315-75-0)

Guidance literature:

at 80 ℃; for 54h; Inert atmosphere;

upstream raw materials:

lauric acid

N₆-[(benzyloxy)carbonyl]-L-lysine

n-dodecanoyl chloride

sodium salt of L-lysine

Downstream raw materials:

lauric acid

L-lysine

N^α,N^ε-bis(1-oxododecyl)-L-lysine

N_α-lauroyl-N_ε-isothiocyanato-L-lysine

Refernces

• 1、 -. "Novel compound N-2-alkylacryl-N-6-fluorenylmethoxycarbonyl-L-lysine". . . Retrieved 2019/05/22.
• 2、 -. "METHOD FOR TREATING SKIN CANCER". Paragraph 0049. . Retrieved 2014/02/16.