Uridine(5')disodiodiphospho(1)-alpha-D-glucose

Base Information

• Chemical Name: Uridine(5')disodiodiphospho(1)-alpha-D-glucose
• CAS No.: 28053-08-9
• Molecular Formula: C₁₅H₂₂N₂O₁₇P₂*2Na
• Molecular Weight: 610.27
• Hs Code.: 29400090
• European Community (EC) Number: 248-801-6,683-053-8
• UNII: UYD77NZ2JQ
• DSSTox Substance ID: DTXSID60182331
• ChEMBL ID: CHEMBL5081317
• Mol file: 28053-08-9.mol

Synonyms:28053-08-9;UDPG sodium salt;Uridine(5')disodiodiphospho(1)-alpha-D-glucose;Uridine 5'-diphosphoglucose disodium;UYD77NZ2JQ;Uridine 5'-diphosphoglucose disodium salt;disodium;[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate;((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl ((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)diphosphate sodium;Uridine 5'-diphosphoglucose disodium salt hydrate;Toxepasi (TN);117756-22-6;DisodiumUDP-glucose;Bivitox (TN);UDP-Glucose sodium salt;UNII-UYD77NZ2JQ;Cogalactoisomerase sodium salt;UDP-a-D-Glucose sodium salt;COGALACTOISOMERASE SODIUM;CHEMBL5081317;DTXSID60182331;EINECS 248-801-6;Uridine 5'-diphosphoglucose disodium salt from Saccharomyces cerevisiae;AKOS025312542;Uridine 5'-diphosphoglucose disodium sal;COGALACTOISOMERASE SODIUM [WHO-DD];D07738;A855605;J-700267;Uridine 5'-diphosphoglucose disodium salt, >=98.0% (HPLC);URIDINE 5'-(TRIHYDROGEN DIPHOSPHATE), P'-.ALPHA.-D-GLUCOPYRANOSYL ESTER, SODIUM SALT (1:2)

Chemical Property of Uridine(5')disodiodiphospho(1)-alpha-D-glucose

Chemical Property:

• PSA: 330.11000
• LogP: -4.07470
• Storage Temp.: −20°C
• Solubility.: H2O: soluble50mg/mL, clear
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 9
• Exact Mass: 610.01890980
• Heavy Atom Count: 38
• Complexity: 948

Purity/Quality:

99% ^*data from raw suppliers

Uridine 5'-Diphosphoglucose Disodium Salt ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OC3C(C(C(C(O3)CO)O)O)O)O)O.[Na+].[Na+]
• Isomeric SMILES: C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)([O-])O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)O.[Na+].[Na+]
• Uses: Uridine 5'-diphosphoglucose disodium salt is a phosphorylated uridine derivative used in nucleotide sugars metabolism as an activated form of glucose as a substrate for the enzyme glucosyltransferases. It is used in the treatment of chronic alco holism. It is used in characterization of limonoid glucosyltransferase. Glc transferase substrate Disodium UDP-glucose is a phosphorylated uridine derivative used in nucleotide sugars metabolism as an activated form of glucose as a substrate for the enzyme glucosyltransferases. It is used in the treatment of chronic alcoholism. It is used in characterization of limonoid glucosyltransferase.

Technology Process of Uridine(5')disodiodiphospho(1)-alpha-D-glucose

There total 1 articles about Uridine(5')disodiodiphospho(1)-alpha-D-glucose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

galactose-α-1-phosphate barium salt (14795-21-2,38987-77-8,51306-18-4,71662-16-3,103213-39-4,120612-21-7,121376-40-7) + uridine 5'-triphosphate trisodium salt (1476-50-2,14264-46-1,19817-92-6,36051-69-1,74674-72-9) → uridine-5'-diphosphogalactose disodium salt (6858-46-4,7333-33-7,14656-80-5,28053-08-9,53829-41-7,108320-88-3,137868-52-1,2956-16-3)

Guidance literature:

With uridine 5'-diphosphoglucose disodium salt; galactose-1-phosphate uridyltransferase, UDP-glucose pyrophosphorylase, pyrophosphatase, pH 8.5;

DOI:10.1021/jo00027a029

Reference yield: 99.0%

12-[N-(5-oxohexanoyl)-l-phenylalanyl-l-glutamyl-l-phenylalanyl-glycinyl]-aminododecyl 2-acetamido-2-deoxy-β-d-glucopyranoside (1036637-19-0) + uridine-5'-diphosphogalactose disodium salt (6858-46-4,7333-33-7,14656-80-5,28053-08-9,53829-41-7,108320-88-3,137868-52-1,2956-16-3) → 12-[N-(5-oxohexanoyl)-l-phenylalanyl-l-glutamyl-l-phenylalanyl-glycinyl]-aminododecyl O-(β-d-galactopyranosyl)-(1→4)-2-acetamido-2-deoxy-β-d-glucopyranoside (1036637-21-4)

Guidance literature:

With β1,4-galactosyltransferase; cyclomaltooctaose; manganese(ll) chloride; In water; at 25 ℃; pH=7.0;

DOI:10.1016/j.tetlet.2008.03.103

Reference yield: 82.0%

C30H40N4O15 + uridine-5'-diphosphogalactose disodium salt (6858-46-4,7333-33-7,14656-80-5,28053-08-9,53829-41-7,108320-88-3,137868-52-1,2956-16-3) → C36H50N4O20

Guidance literature:

With β-1,4-galactosyltransferase (LgtB); manganese(ll) chloride; In aq. buffer; at 37 ℃; for 3h; Enzymatic reaction;

DOI:10.1021/acs.jmedchem.9b00303

upstream raw materials:

galactose-α-1-phosphate barium salt

uridine 5'-triphosphate trisodium salt

Downstream raw materials:

(5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranulosonic acid)-(2,6)-β-D-galactopyranosyl-(1,4)-2-acetamido-2-deoxyglucopyranose

N⁴-<(5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranulosonic acid)-(2,6)-β-D-galactopyranosyl-(1,4)-2-acetamido-2-deoxy-β-D-glucopyranosyl>-N²-<(allyloxy)carbonyl-L-phenylalanyl>-L-asparaginyl-L-seryl-L-threonyl-L-isoleucine

[1-¹³C₁]-β-D-fructofuranosyl α-D-glucopyranoside

uridine-5'-diphosphate-2-deoxy-2-fluorogalactose

Refernces