(Pentafluorophenyl)glycolic acid

Base Information

• Chemical Name: (Pentafluorophenyl)glycolic acid
• CAS No.: 652-24-4
• Molecular Formula: C8H3 F5 O3
• Molecular Weight: 242.102
• European Community (EC) Number: 211-486-0
• DSSTox Substance ID: DTXSID40983782
• Nikkaji Number: J205.931B
• Mol file: 652-24-4.mol

Synonyms:(Pentafluorophenyl)glycolic acid;652-24-4;Pentafluoromandelic acid;2-hydroxy-2-(2,3,4,5,6-pentafluorophenyl)acetic acid;2,3,4,5,6-pentafluoromandelic acid;EINECS 211-486-0;MFCD00014337;hydroxy(pentafluorophenyl)acetic acid;SCHEMBL7471164;DTXSID40983782;AKOS023119026;DL-2,3,4,5,6-Pentafluoromandelic acid;SY315018;2-hydroxy-2-(pentafluorophenyl)acetic acid;CS-0267391;EN300-1850873;2,3,4,5,6-Pentafluoro-a-hydroxybenzeneacetic acid;alpha-Hydroxy-2,3,4,5,6-pentafluorobenzeneacetic acid

Chemical Property of (Pentafluorophenyl)glycolic acid

Chemical Property:

• Vapor Pressure: 0.00223mmHg at 25°C
• Boiling Point: 277.1°C at 760 mmHg
• Flash Point: 121.4°C
• Density: 1.777g/cm³
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 2
• Exact Mass: 242.00023476
• Heavy Atom Count: 16
• Complexity: 260

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1(=C(C(=C(C(=C1F)F)F)F)F)C(C(=O)O)O

Technology Process of (Pentafluorophenyl)glycolic acid

There total 7 articles about (Pentafluorophenyl)glycolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

perfluorobenzaldehyde (653-37-2) → 2-hydroxy-2-(2,6-difluorophenyl)acetic acid (207981-50-8) + (pentafluorophenyl)glycolic acid (652-24-4)

Guidance literature:

Reference yield:

ethyl pentafluorophenylglycolate (51978-44-0) → (pentafluorophenyl)glycolic acid (652-24-4)

Guidance literature:

With potassium hydroxide; In ethanol;

Reference yield:

pentafluorophenylmagnesium chloride (879-06-1) → (pentafluorophenyl)glycolic acid (652-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / 2 h / heating on water bath

2: KOH / ethanol

With potassium hydroxide; In ethanol;

upstream raw materials:

ethyl pentafluorophenylglycolate

perfluorobenzaldehyde

potassium cyanide

pentafluorophenylmagnesium chloride

Downstream raw materials:

2-Pentafluorphenyl-2-hydroxy-1-phenyl-ethanon

Refernces

• 1、 Shadrina, L. P.,Dormidontov, Yu. P.. "REACTION OF PENTAFLUOROPHENYLMAGNESIUM CHLORIDE WITH THE ESTERS OF DIBASIC ACIDS". . p. 1251 - 1255. Retrieved 2007/10/02.