inositol 3,4-bisphosphate

Base Information

• Chemical Name: inositol 3,4-bisphosphate
• CAS No.: 23410-61-9
• Molecular Formula: C₆H₁₄O₁₂P₂
• Molecular Weight: 340.117
• Mol file: 23410-61-9.mol

Synonyms:Inositol,1,2-bis(dihydrogen phosphate), D-myo- (8CI); D-Ins(1,2)P2; D-myo-Inositol1,2-diphosphate

Chemical Property of inositol 3,4-bisphosphate

Chemical Property:

• Vapor Pressure: 7.85E-22mmHg at 25°C
• Boiling Point: 686.8°Cat760mmHg
• Flash Point: 369.1°C
• Density: 2.15g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of inositol 3,4-bisphosphate

There total 9 articles about inositol 3,4-bisphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-1,4-Di-O-benzyl-myo-inositol 5,6-bis(dibenzyl phosphate) → (+/-)-myo-inositol 4,5-bisphosphate (23410-61-9,41613-00-7,41613-01-8,69256-53-7,69256-54-8,74465-15-9,74465-17-1,93060-87-8,95120-19-7,109584-32-9,131321-70-5,131321-71-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 12h; under 760 Torr; Yield given;

Reference yield:

(5S,6S)-5,6-Bis-(2-methoxy-ethoxymethoxy)-cyclohex-2-ene-1,4-dione (130659-82-4) → (+/-)-myo-inositol 4,5-bisphosphate (23410-61-9,41613-00-7,41613-01-8,69256-53-7,69256-54-8,74465-15-9,74465-17-1,93060-87-8,95120-19-7,109584-32-9,131321-70-5,131321-71-6)

Guidance literature:

Multi-step reaction with 7 steps

1: NaBH₄, CeCl₃

2: 95 percent / NaH

3: 96 percent / OsO₄, N-methylmorpholine-N-oxide

4: NaH

5: 6 M HCl / tetrahydrofuran / 20 °C

6: BuLi / tetrahydrofuran

7: H₂ / Pd/C

With hydrogenchloride; sodium tetrahydroborate; osmium(VIII) oxide; n-butyllithium; cerium(III) chloride; hydrogen; sodium hydride; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)97419-7

Reference yield:

(1R,2S,3S,4R,5R,6S)-3,6-Bis-benzyloxy-4,5-bis-(2-methoxy-ethoxymethoxy)-cyclohexane-1,2-diol (129662-36-8,130792-09-5) → (+/-)-myo-inositol 4,5-bisphosphate (23410-61-9,41613-00-7,41613-01-8,69256-53-7,69256-54-8,74465-15-9,74465-17-1,93060-87-8,95120-19-7,109584-32-9,131321-70-5,131321-71-6)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH

2: 6 M HCl / tetrahydrofuran / 20 °C

3: BuLi / tetrahydrofuran

4: H₂ / Pd/C

With hydrogenchloride; n-butyllithium; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)97419-7

upstream raw materials:

(+/-)-1,2,3,4-Tetra-O-benzyl-myo-inositol 5,6-bis(dinbenzyl phosphate)

(±)-1,2-O-isopropylidene-3,6-di-O-benzyl-myo-inositol

(5S,6S)-5,6-Bis-(2-methoxy-ethoxymethoxy)-cyclohex-2-ene-1,4-dione

C₂₈H₃₈O₈

Refernces

• 1、 Carless, Howard A. J.,Busia, Kofi. "Total synthesis of myo-inositol polyphosphates from benzene via conduritol B derivatives". . p. 3449 - 3452. Retrieved 2007/10/02.