N-(4-hydroxyphenyl)-4-nitrobenzenesulfonamide

Base Information

• Chemical Name: N-(4-hydroxyphenyl)-4-nitrobenzenesulfonamide
• CAS No.: 50994-51-9
• Molecular Formula: C12H10 N2 O5 S
• Molecular Weight: 294.288
• Mol file: 50994-51-9.mol

Synonyms:NSC 529157

Chemical Property of N-(4-hydroxyphenyl)-4-nitrobenzenesulfonamide

Chemical Property:

• Vapor Pressure: 1.52E-11mmHg at 25°C
• Boiling Point: 522.7°Cat760mmHg
• Flash Point: 269.9°C
• Density: 1.558g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-hydroxyphenyl)-4-nitrobenzenesulfonamide

There total 6 articles about N-(4-hydroxyphenyl)-4-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

p-aminophenol hydrochloride (51-78-5) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → N-(4-hydroxyphenyl)-4-nitrobenzenesulfonamide (50994-51-9)

Guidance literature:

In pyridine; at 20 ℃; for 5h; Cooling with ice;

DOI:10.1016/j.ejmech.2013.07.056

Reference yield: 30.0%

(E)-ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate (1441409-91-1) + 4-amino-phenol (123-30-8) → N-(4-hydroxyphenyl)-4-nitrobenzenesulfonamide (50994-51-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 3h; Green chemistry;

DOI:10.1002/ejoc.201201571

Reference yield:

4-amino-phenol (123-30-8) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → N-(4-hydroxyphenyl)-4-nitrobenzenesulfonamide (50994-51-9)

Guidance literature:

In pyridine; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

upstream raw materials:

4-nitro-N-(4-oxocyclohexa-2,5-dien-1-ylidene)benzenesulfonamide

4-amino-phenol

4-Nitrobenzenesulfonyl chloride

(E)-ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate

Downstream raw materials:

N-(3-((7H-purin-6-yl)thio)-4-hydroxyphenyl)-4-nitrobenzenesulfonamide

4-nitro-N-(4-oxocyclohexa-2,5-dien-1-ylidene)benzenesulfonamide

N-(3-((1H-1,2,4-triazol-5-yl)thio)-4-hydroxyphenyl)-4-nitrobenzenesulfonamide

N-(4-hydroxy-3-((5-methyl-1,3,4-thiadiazol-2-yl)thio)phenyl)-4-nitrobenzenesulfonamide

Refernces

• 1、 Chen, Hui,Zhao, Sihan,Cheng, Shaobing,Dai, Xingjie,Xu, Xiaoying,Yuan, Weicheng,Zhang, Xiaomei. "Synthesis of Novel Pterocarpen Analogues via [3?+?2] Coupling-Elimination Cascade of α,α-Dicyanoolefins with Quinone Monoimines". . p. 1672 - 1683. Retrieved 2019/04/08.
• 2、 Palakurthy, Nani Babu,Dev, Dharm,Rana, Shubhasmin,Nadimpally, Krishna Chaitanya,Mandal, Bhubaneswar. "Sulfonamide synthesis via oxyma-O-sulfonates - Compatibility to acid sensitive groups and solid-phase peptide synthesis". . p. 2627 - 2633. Retrieved 2013/06/04.