6-HYDROXYLAMINOURACIL

Base Information

• Chemical Name: 6-HYDROXYLAMINOURACIL
• CAS No.: 20555-88-8
• Molecular Formula: C4H5N3O2
• Molecular Weight: 127.103
• Hs Code.: 2933599090
• Mol file: 20555-88-8.mol

Synonyms:2,4(1H,3H)-Pyrimidinedione,4-oxime (9CI);Uracil, 4-oxime (8CI);N4-Hydroxycytosine;

Chemical Property of 6-HYDROXYLAMINOURACIL

Chemical Property:

• Refractive Index: 1.687
• PSA: 97.98000
• Density: 1.65 g/cm³
• LogP: -1.06270
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

N4-Hydroxycytosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N4-Hydroxycytosine is a useful research chemical. N4-Hydroxycytosine is a ribonucleotide analogue.

Technology Process of 6-HYDROXYLAMINOURACIL

There total 8 articles about 6-HYDROXYLAMINOURACIL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.7%

Cytosine (71-30-7) → N4-hydroxycytosine (20555-88-8)

Guidance literature:

With sodium acetate; hydroxylamine sulfate; In ethanol; water; at 55 - 65 ℃; pH=5 - 7; Reagent/catalyst;

Reference yield: 93.7%

Cytosine (71-30-7) → N4-hydroxycytosine (20555-88-8)

Guidance literature:

With hydroxyammonium sulfate; sodium methylate; In ethanol; water; at 55 - 65 ℃; pH=5 - 7; Reagent/catalyst;

Reference yield: 78.0%

4-methylsulfanylpyrimidin-2(1H)-one (35551-31-6) → N4-hydroxycytosine (20555-88-8)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; for 5h; Reflux;

DOI:10.1016/j.ejmech.2008.06.002

upstream raw materials:

Cytosine

4-methylsulfanylpyrimidin-2(1H)-one

4-hydroxyimino-5,6-dihydro-6-hydroxyaminopyrimidin-2(1H)-one

Downstream raw materials:

Cytosine

Refernces

• 1、 -. "Preparation method of N4-hydroxycytidine". Paragraph 0018; 0041-0044. . Retrieved 2021/08/28.
• 2、 Atkins, Paul J.,Palling, David J.,Poon, Nai L.,Hall, C. Dennis. "Deuterium Isotope Effects and the Bunnet w Factor in Elimination Reactions of 4-Alkoxyimino-5,6-dihydro-6-alkoxyaminopyrimidin-2(1H)-one in Strong Acid Media". . p. 1107 - 1112. Retrieved 2007/10/02.