2-Cyano-2-MethylpropanaMide

Base Information

• Chemical Name: 2-Cyano-2-MethylpropanaMide
• CAS No.: 7505-93-3
• Molecular Formula: C5H8N2O
• Molecular Weight: 112.131
• Hs Code.: 2926909090
• Mol file: 7505-93-3.mol

Synonyms:2-cyano-2-methyl-propionic acid amide;2-Cyan-2-methyl-propionsaeure-amid;2-cyano-2-methyl-propanamide;

Chemical Property of 2-Cyano-2-MethylpropanaMide

Chemical Property:

• Vapor Pressure: 0.00287mmHg at 25°C
• Boiling Point: 285.1°C at 760 mmHg
• Flash Point: 126.2°C
• PSA: 66.88000
• Density: 1.064g/cm³
• LogP: 0.72178
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Cyano-2-methylpropanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Cyano-2-MethylpropanaMide

There total 5 articles about 2-Cyano-2-MethylpropanaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,2-dimethyl-3-oximinoadipamide (86439-20-5) → 2-cyano-2-methylpropanamide (7505-93-3)

Guidance literature:

at 140 - 150 ℃; for 72h; under 0.3 Torr;

Reference yield: 81.0%

methyl 2,2-dimethyl-cyanoacetate (72291-30-6) → 2-cyano-2-methylpropanamide (7505-93-3)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 15h;

Reference yield: 70.0%

2-cyano-2-methylpropanoic acid (22426-30-8) → 2-cyano-2-methylpropanamide (7505-93-3)

Guidance literature:

2-cyano-2-methylpropanoic acid; With 1,1'-carbonyldiimidazole; In ethyl acetate; at 50 ℃; for 1h; Inert atmosphere;

With ammonium hydroxide; In ethyl acetate; at 20 ℃; for 0.5h;

upstream raw materials:

cyanoacetic acid amide

methyl iodide

2,2-dimethyl-3-oximinoadipamide

methyl 2,2-dimethyl-cyanoacetate

Downstream raw materials:

(2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxypropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-(2-propan-2-yl)nonanamide hemifumarate

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

2-Cyan-2-methyl-propionsaeure-dianilinophosphorylamid

(2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide

Refernces

• 1、 Patrick, Donald A.,Gillespie, J. Robert,McQueen, Joshua,Hulverson, Matthew A.,Ranade, Ranae M.,Creason, Sharon A.,Herbst, Zackary M.,Gelb, Michael H.,Buckner, Frederick S.,Tidwell, Richard R.. "Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis". supporting information. p. 957 - 971. Retrieved 2017/02/19.
• 2、 -. "PROCESS FOR PREPARING ALISKIREN AND ITS INTERMEDIATES". Page/Page column 29-30. . Retrieved 2012/03/09.