H-Lys(Boc)-OtBu.HCl

Base Information

• Chemical Name: H-Lys(Boc)-OtBu.HCl
• CAS No.: 13288-57-8
• Molecular Formula: C15H30N2O4^.HCl
• Molecular Weight: 338.875
• Hs Code.: 2924199090
• European Community (EC) Number: 870-190-5
• Mol file: 13288-57-8.mol

Synonyms:13288-57-8;H-Lys(Boc)-OtBu.HCl;H-Lys(Boc)-OtBu HCl;Ne-Boc-L-lysine tert-butyl ester hydrochloride;H-Lys(Boc)-Obut HCl;H-Lys(Boc)-OtBu hydrochloride;H-L-Lys(Boc)-OtBu*HCl;L-Lysine, N6-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester, hydrochloride (1:1);Nepsilon-Boc-L-lysine tert-Butyl Ester Hydrochloride;MFCD00038899;Lys(BOC)-OtBu HCl;H-Lys(Boc)-Obut hydrochloride;SCHEMBL2216656;TZBPQINFXPIRBX-MERQFXBCSA-N;AMY30892;BCP11647;AKOS015918293;CS-W005295;HY-W005295;H-Lys(Boc)-OtBu Hydrochloric Acid Salt;DS-16186;F10611;tert-Butyl N6-(tert-butoxycarbonyl)-L-lysinate hydrochloride;N-epsilon-t-Butyloxycarbonyl-L-lysine t-butyl ester hydrochloride;(s)-tert-butyl 2-amino-6-(tert-butoxycarbonylamino)hexanoate hydrochloride;Nepsilon-tert-butyloxycarbonyl-L-lysine tert-butyl ester hydrochloride;tert-butyl (S)-2-amino-6-tert-butoxycarbonylaminohexanoate hydrochloride;tert-butyl(s)-2-amino-6-tert-butoxycarbonylaminohexanoate hydrochloride;(S)-tert-butyl 2-amino-6-((tert-butoxycarbonyl)amino)hexanoate hydrochloride;tert-butyl (2S)-2-amino-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoate hydrochloride;tert-butyl (2S)-2-amino-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoate;hydrochloride

Chemical Property of H-Lys(Boc)-OtBu.HCl

Chemical Property:

• Vapor Pressure: 1.54E-06mmHg at 25°C
• Melting Point: 139-140 °C
• Refractive Index: 1.466
• Boiling Point: 397.8oC at 760 mmHg
• Flash Point: 194.4oC
• PSA: 90.65000
• Density: 1.021g/cm3
• LogP: 4.24360
• Storage Temp.: -15°C
• Solubility.: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
• Water Solubility.: Insoluble in water.
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 10
• Exact Mass: 338.1972352
• Heavy Atom Count: 22
• Complexity: 343

Purity/Quality:

98%,99%, ^*data from raw suppliers

H-Lys(Boc)-OtBuHydrochloricAcidSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)C(CCCCNC(=O)OC(C)(C)C)N.Cl
• Isomeric SMILES: CC(C)(C)OC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)N.Cl
• Uses: Nepsilon-Boc-L-lysine tert-butyl ester hydrochloride is an pharmaceutical intermediate.

Technology Process of H-Lys(Boc)-OtBu.HCl

There total 3 articles about H-Lys(Boc)-OtBu.HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Lys(εBoc)-OtBu (7750-44-9) → 1,1-dimethylethyl N6-{[(1,1-dimethylethyl)oxy]carbonyl}-L-lysinate hydrochloride (13288-57-8)

Guidance literature:

With hydrogen; In N,N-dimethyl-formamide;

DOI:10.1002/recl.19831021101

Reference yield:

Z-Lys(Boc)-OH (2389-60-8) → 1,1-dimethylethyl N6-{[(1,1-dimethylethyl)oxy]carbonyl}-L-lysinate hydrochloride (13288-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 47.5 percent / CH₂Cl₂ / 42 h / Ambient temperature

2: H₂ / dimethylformamide

With hydrogen; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/recl.19831021101

Reference yield:

N,N-dimethylformamide di-tert-butyl acetal (36805-97-7) → 1,1-dimethylethyl N6-{[(1,1-dimethylethyl)oxy]carbonyl}-L-lysinate hydrochloride (13288-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 47.5 percent / CH₂Cl₂ / 42 h / Ambient temperature

2: H₂ / dimethylformamide

With hydrogen; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/recl.19831021101

upstream raw materials:

Z-Lys(εBoc)-OtBu

Z-Lys(Boc)-OH

N,N-dimethylformamide di-tert-butyl acetal

Downstream raw materials:

(S)-6-tert-Butoxycarbonylamino-2-{2-[2-((S)-1-tert-butoxycarbonyl-5-tert-butoxycarbonylamino-pentylcarbamoyl)-phenyldisulfanyl]-benzoylamino}-hexanoic acid tert-butyl ester

N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-(tert-butoxycarbonyl)-L-lysine tert-butyl ester

Z-Asp(OBu^t)-Lys(Boc)-OBu^t

tert-butyl (5S,8S)-5-isobutyl-16,16-dimethyl-3,6,14-trioxo-1-phenyl-2,15-dioxa-4,7,13-triazaheptadecane-8-carboxylate

Refernces