Ethyl 1-aminocyclopentanecarboxylate hydrochloride

Base Information

• Chemical Name: Ethyl 1-aminocyclopentanecarboxylate hydrochloride
• CAS No.: 22649-37-2
• Molecular Formula: C8H15 N O2 . Cl H
• Molecular Weight: 193.674
• Hs Code.: 2922499990
• European Community (EC) Number: 823-507-6
• NSC Number: 176957
• DSSTox Substance ID: DTXSID00945321
• Mol file: 22649-37-2.mol

Synonyms:Ethyl 1-aminocyclopentanecarboxylate hydrochloride;22649-37-2;ethyl 1-aminocyclopentane-1-carboxylate;hydrochloride;Cyclopentanecarboxylic acid, 1-amino-, ethyl ester, hydrochloride;1-Amino-cyclopentanecarboxylic acid ethyl ester hydrochloride;ethyl 1-aminocyclopentane-1-carboxylate hydrochloride;cycloleucine ethyl ester hydrochloride;Ethyl1-aminocyclopentanecarboxylatehydrochloride;1-Amino-cyclopentanecarboxylic acid ethyl ester HCl;SCHEMBL1279085;NIOSH/GY2625150;DTXSID00945321;ADFASIQRQWKXSJ-UHFFFAOYSA-N;MFCD01735325;NSC176957;AKOS016014557;CB 1691;NSC-176957;BS-36789;Ethyl 1-amino-cyclopentanecarboxylate HCl;LS-57868;CS-0433696;GY26251500;EN300-54278;F79118;ethyl-1-amino-1-cyclopentanoate hydrochloride salt;1-AMINO-CYCLOPENTANECARBOXYLICACIDETHYLESTERHCL;Z818732108;Ethyl 1-aminocyclopentane-1-carboxylate--hydrogen chloride (1/1);1-Amino-cyclopentanecarboxylic acid ethyl ester hydrochloride, AldrichCPR

Chemical Property of Ethyl 1-aminocyclopentanecarboxylate hydrochloride

Chemical Property:

• PSA: 52.32000
• LogP: 2.32330
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 193.0869564
• Heavy Atom Count: 12
• Complexity: 150

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl1-amino-cyclopentanecarboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1(CCCC1)N.Cl

Technology Process of Ethyl 1-aminocyclopentanecarboxylate hydrochloride

There total 4 articles about Ethyl 1-aminocyclopentanecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Wang-benzaldehyde resin, imine with glycine ethyl ester + 1,4-dibromo-butane (110-52-1) → 1-amino-cyclopentanecarboxylic acid ethyl ester hydrochloride (22649-37-2)

Guidance literature:

Wang-benzaldehyde resin, imine with glycine ethyl ester; 1,4-dibromo-butane; In 1-methyl-pyrrolidin-2-one; for 1h;

With tert-butylimino-tri(pyrrolidino)phosphorane; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 14h;

With hydrogenchloride; In tetrahydrofuran; for 5h;

DOI:10.1039/b505881c

Reference yield: 93.0%

→ 1-amino-cyclopentanecarboxylic acid ethyl ester hydrochloride (22649-37-2)

Guidance literature:

Reference yield: 83.0%

ethanol (64-17-5) + 1-amino-1-cyclopentanecarboxylic acid (52-52-8) → 1-amino-cyclopentanecarboxylic acid ethyl ester hydrochloride (22649-37-2)

Guidance literature:

With thionyl chloride; for 4h; Heating;

DOI:10.1139/v92-171

upstream raw materials:

ethanol

1-amino-1-cyclopentanecarboxylic acid

1,4-dibromo-butane

Downstream raw materials:

6,9-diaza-7,10-dioxospiro<4,5>decane

1-(2,4-difluorophenyl)-6-fluoro-7-(6,9-diazaspiro<4,5>decan-9-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylic acid trifluoroacetic acid salt

1-(2,4-difluorophenyl)-6-fluoro-7-(6,9-diazaspiro<4,5>decan-9-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride

ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(6,9-diazaspiro<4,5>decan-9-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylate

Refernces

• 1、 Fish, Paul V.,Barber, Christopher G.,Brown, David G.,Butt, Richard,Collis, Michael G.,Dickinson, Roger P.,Henry, Brian T.,Horne, Valerie A.,Huggins, John P.,King, Elizabeth,O'Gara, Margaret,McCleverty, Dawn,McIntosh, Fraser,Phillips, Christopher,Webster, Robert. "Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines". . p. 2341 - 2351. Retrieved 2008/02/03.
• 2、 -. "CHEMICAL COMPOUNDS". Page/Page column 20. . Retrieved 2010/02/10.