1-BIPHENYL-4-YL-PROPAN-2-ONE

Base Information

• Chemical Name: 1-BIPHENYL-4-YL-PROPAN-2-ONE
• CAS No.: 5333-01-7
• Molecular Formula: C15H14O
• Molecular Weight: 210.276
• Hs Code.: 2914399090
• Mol file: 5333-01-7.mol

Synonyms:Biphenyl-4-yl-aceton;biphenyl-4-yl-acetone;p-biphenylacetone;1-biphenyl-4-ylpropan-2-one;

Chemical Property of 1-BIPHENYL-4-YL-PROPAN-2-ONE

Chemical Property:

• Vapor Pressure: 8.74E-05mmHg at 25°C
• Boiling Point: 340.2°Cat760mmHg
• Flash Point: 164.4°C
• PSA: 17.07000
• Density: 1.045g/cm³
• LogP: 3.48510

Purity/Quality:

99%min ^*data from raw suppliers

1-?Biphenyl-?4-?yl-?propan-?2-?one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BIPHENYL-4-YL-PROPAN-2-ONE

There total 3 articles about 1-BIPHENYL-4-YL-PROPAN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-Methoxypropene (116-11-0) + 4-iodo-biphenyl (1591-31-7) → biphenyl (92-52-4,1594-86-1) + 1-(4-biphenylyl)-2-propanone (5333-01-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at -78 - 25 ℃; for 17h; Irradiation; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.0c03935

Reference yield: 15.0%

cyclohexane (110-82-7,25012-93-5) + 4-iodo-biphenyl (1591-31-7) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → biphenyl (92-52-4,1594-86-1) + 1-phenyl-1-cyclohexane (827-52-1,5379-26-0) + 1-(4-biphenylyl)-2-propanone (5333-01-7) + methyl 2-([1,1'-biphenyl]-4-yl)-3-cyclohexylpropanoate

Guidance literature:

With potassium phosphate; tetrakis(tetrabutylammonium)decatungstate(VI); 4,4'-di-tert-butyl-2,2'-bipyridine nickel(II) bromide; In acetone; at 30 ℃; for 18h; regioselective reaction; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/anie.202014632

Reference yield:

4-propyl-1,1'-biphenyl (10289-45-9) → 1-(4-biphenylyl)-2-propanone (5333-01-7) + 4-Phenylbenzaldehyde (3218-36-8)

Guidance literature:

With dichloro-acetic acid; bis(dimethylglyoximatodifluoroboryl)cobalt(II); 3,6‐di‐tert‐butyl‐9‐(4‐fluoro‐2,6‐dimethylphenyl)‐10‐phenylacridin‐10‐ium tetrafluoroborate; lithium nitrate; water; In acetonitrile; for 20h; Inert atmosphere; Irradiation;

DOI:10.1021/jacs.0c04422

upstream raw materials:

4-propyl-1,1'-biphenyl

2-Methoxypropene

4-iodo-biphenyl

cyclohexane

Downstream raw materials:

C₁₉H₁₆N₂O₅

C₁₉H₁₆N₂O₅

3-(biphenyl-4-yl)-1,2-diphenylpentane-1,4-dione

(E)-N-<2-(4-Biphenylyl)-1-methylethyliden>benzolamin

Refernces

• 1、 Xu, Sheng,Chen, Herong,Zhou, Zhijun,Kong, Wangqing. "Three-Component Alkene Difunctionalization by Direct and Selective Activation of Aliphatic C?H Bonds". supporting information. p. 7405 - 7411. Retrieved 2021/02/20.