8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid

Base Information Edit

Chemical Name:8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid
CAS No.:59468-44-9
Molecular Formula:C19H13 Cl F N3 O2
Molecular Weight:369.783
Hs Code.:
European Community (EC) Number:261-777-1
UNII:P5URY5OSB9
DSSTox Substance ID:DTXSID90208174
Nikkaji Number:J298.167J
Mol file:59468-44-9.mol

Synonyms:59468-44-9;8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid;8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid;8-chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid;EINECS 261-777-1;P5URY5OSB9;C19H13ClFN3O2;Midazolam impurity C;Midazolam EP Impurity C;UNII-P5URY5OSB9;SCHEMBL1311112;DTXSID90208174;C19-H13-Cl-F-N3-O2;AKOS027307615;CS-O-13579;MIDAZOLAM IMPURITY C [EP IMPURITY];4H-IMIDAZO(1,5-A)(1,4)BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-CHLORO-6-(2-FLUOROPHENYL)-1-METHYL-

Suppliers and Price of 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Midazolam impurity C European Pharmacopoeia (EP) Reference Standard
y0000562
$ 190.00

Total 7 raw suppliers

Chemical Property of 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid Edit

Chemical Property:

Vapor Pressure:8.47E-15mmHg at 25°C
Boiling Point:590.7°C at 760 mmHg
PKA:6.11±0.40(Predicted)
Flash Point:311°C
PSA：67.48000
Density:1.47g/cm³
LogP:3.45800
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:369.0680325
Heavy Atom Count:26
Complexity:589

Purity/Quality:

99.9% ^*data from raw suppliers

Midazolam impurity C European Pharmacopoeia (EP) Reference Standard ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC(=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F)C(=O)O
Uses 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic Acid is an imidazodiaepine derivative and an impurity of Midazolam (M343000), an anesthetic, anticonvulsant, seda tive and hypotic agent.

Technology Process of 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid

There total 4 articles about 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 8-chloro-5-(2-fluorophenyl)-α-(hydroxyimino)-3H-1,4-benzodiazepine-2-acetate

: 59468-44-9
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid

Guidance literature:: methyl 8-chloro-5-(2-fluorophenyl)-α-(hydroxyimino)-3H-1,4-benzodiazepine-2-acetate; With hydrogen; toluene-4-sulfonic acid; Triethyl orthoacetate; nickel; In tetrahydrofuran; methanol; for 16h; under 1551.49 Torr;

With potassium hydroxide; In water; at 30 ℃; for 2h;