1-Ethyl-2,2,6,6-tetramethylpiperidine

Base Information

• Chemical Name: 1-Ethyl-2,2,6,6-tetramethylpiperidine
• CAS No.: 32163-58-9
• Molecular Formula: C11H23N
• Molecular Weight: 169.31
• DSSTox Substance ID: DTXSID20185949
• Nikkaji Number: J50.665F
• Wikidata: Q83057122
• Mol file: 32163-58-9.mol

Synonyms:1-Ethyl-2,2,6,6-tetramethylpiperidine;32163-58-9;Piperidine, 1-ethyl-2,2,6,6-tetramethyl-;BRN 0104404;5-20-04-00238 (Beilstein Handbook Reference);SCHEMBL1555233;DTXSID20185949

Chemical Property of 1-Ethyl-2,2,6,6-tetramethylpiperidine

Chemical Property:

• Vapor Pressure: 1.51mmHg at 25°C
• Boiling Point: 169.9°C at 760 mmHg
• Flash Point: 64.8°C
• Density: 0.798g/cm³
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 169.183049738
• Heavy Atom Count: 12
• Complexity: 142

Purity/Quality:

97% ^*data from raw suppliers

1-ETHYL-2,2,6,6-TETRAMETHYLPIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1C(CCCC1(C)C)(C)C

Technology Process of 1-Ethyl-2,2,6,6-tetramethylpiperidine

There total 3 articles about 1-Ethyl-2,2,6,6-tetramethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2,2,6,6-tetramethyl-piperidine (768-66-1) + ethyl iodide (75-03-6) → 1-Ethyl-2,2,6,6-tetramethylpiperidine (32163-58-9)

Guidance literature:

2,2,6,6-tetramethyl-piperidine; With potassium carbonate; In acetonitrile; at 85 ℃; for 1h; Inert atmosphere;

ethyl iodide; for 48h; Inert atmosphere; Reflux;

DOI:10.1021/om100951a

Reference yield:

2,2,6,6-tetramethyl-piperidine (768-66-1) + ethyl ester of p-toluenesulfonic acid (80-40-0) → 1-Ethyl-2,2,6,6-tetramethylpiperidine (32163-58-9)

Guidance literature:

DOI:10.1021/ja01577a029

Reference yield:

→ 1-Ethyl-2,2,6,6-tetramethylpiperidine (32163-58-9)

Guidance literature:

1-Acetyl-2,2,6,6-tetramethylpiperidin, LiAlH4;

DOI:10.1039/j39710001653

upstream raw materials:

2,2,6,6-tetramethyl-piperidine

ethyl ester of p-toluenesulfonic acid

ethyl iodide

Downstream raw materials:

(C₆F₅)3BCH₂CHNC₅H₆(CH₃)4

Refernces

• 1、 Belostotskii, Anatoly M.,Gottlieb, Hugo E.,Aped, Pinchas,Hassner, Alfred. "Conformational schemes: An available tool for the assignment of NMR- measured barriers, demonstrated with the example of crowded piperidines". . p. 449 - 455. Retrieved 2007/10/03.