1-Benzoyl-1-bromocyclohexane

Base Information

• Chemical Name: 1-Benzoyl-1-bromocyclohexane
• CAS No.: 7500-66-5
• Molecular Formula: C13H15BrO
• Molecular Weight: 267.166
• Hs Code.: 2914700090
• Mol file: 7500-66-5.mol

Synonyms:1-BENZOYL-1-BROMOCYCLOHEXANE;

Chemical Property of 1-Benzoyl-1-bromocyclohexane

Chemical Property:

• Vapor Pressure: 0.000162mmHg at 25°C
• Boiling Point: 330.9°C at 760 mmHg
• Flash Point: 49.3°C
• PSA: 17.07000
• Density: 1.361g/cm³
• LogP: 3.96710

Purity/Quality:

99% ^*data from raw suppliers

1-BENZOYL-1-BROMOCYCLOHEXANE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (1-Bromocyclohexyl)phenylmethanone is an intermediate in the synthesis of 1-Cyclohexenyl Phenyl Ketone (C992550), a useful reactant in the synthesis of cyclopentanone enol ethers.

Technology Process of 1-Benzoyl-1-bromocyclohexane

There total 4 articles about 1-Benzoyl-1-bromocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Cyclohexyl phenyl ketone (712-50-5) → (1-bromocyclohexyl)(phenyl)methanone (7500-66-5)

Guidance literature:

With hydrogen bromide; dimethyl sulfoxide; In water; ethyl acetate; at 60 ℃; for 6h;

DOI:10.1039/c5gc00528k

Reference yield: 81.0%

C20H24O → (1-bromocyclohexyl)(phenyl)methanone (7500-66-5)

Guidance literature:

With p-nitrobenzenesulfonamide; hydrogen bromide; oxygen; sodium nitrite; In water; acetonitrile; at 0 - 60 ℃; for 30.5h; under 760.051 Torr;

DOI:10.1039/c7cc02166f

Reference yield:

benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → (1-bromocyclohexyl)(phenyl)methanone (7500-66-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / 1.33 h / 10 - 60 °C

2: sodium hypochlorite; hydrogen bromide / water / 2.5 h / 60 - 100 °C

With aluminum (III) chloride; sodium hypochlorite; hydrogen bromide; In water; 1: Friedel Crafts Acylation;

upstream raw materials:

Cyclohexyl phenyl ketone

benzene

cyclohexanylcarbonyl chloride

Downstream raw materials:

C₂₃H₃₄N₂O₅

C₁₃H₁₇BrO

1-phenylcyclohexane-1-carbaldehyde

Cyclohexyl phenyl ketone

Refernces

• 1、 Ding, Rui,Li, Jiaqi,Jiao, Wenyi,Han, Mengru,Liu, Yongguo,Tian, Hongyu,Sun, Baoguo. "A Highly Efficient Method for the Bromination of Alkenes, Alkynes and Ketones Using Dimethyl Sulfoxide and Oxalyl Bromide". . p. 4325 - 4335. Retrieved 2018/11/21.
• 2、 Jarava-Barrera, Carlos,Parra, Alejandro,Amenós, Laura,Arroyo, Ana,Tortosa, Mariola. "Stereoselective Traceless Borylation–Allenation of Propargylic Epoxides: Dual Role of the Copper Catalyst". supporting information. p. 17478 - 17481. Retrieved 2017/11/30.