VANILLIC ACID HYDRAZIDE

Base Information

• Chemical Name: VANILLIC ACID HYDRAZIDE
• CAS No.: 100377-63-7
• Molecular Formula: C8H10N2O3
• Molecular Weight: 182.179
• Hs Code.: 2928000090
• Mol file: 100377-63-7.mol

Synonyms:Vanillic Acid Hydrazide;4-Hydroxy-3-methoxy-benzoesaeure-hydrazid;4-hydroxy-3-methoxy-benzoic acid hydrazide;Vanilloylhydrazin;4-???-2-methoxyphenol;4-hydroxy-3-methoxybenzoic hydrazide;4-hydroxy-3-methoxybenzoylhydrazide;4-Oxy-3-methoxy-benzoylhydrazin;

Chemical Property of VANILLIC ACID HYDRAZIDE

Chemical Property:

• Melting Point: 213-216oC
• PKA: 8.61±0.20(Predicted)
• PSA: 84.58000
• Density: 1.307g/cm3
• LogP: 1.09550

Purity/Quality:

98%Min ^*data from raw suppliers

4-Hydroxy-3-methoxybenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of VANILLIC ACID HYDRAZIDE

There total 7 articles about VANILLIC ACID HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

→ 4-hydroxy-3-methoxybenzoic hydrazide (100377-63-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Reflux;

Reference yield: 88.0%

ethyl vanillate (617-05-0) → 4-hydroxy-3-methoxybenzoic hydrazide (100377-63-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Reflux;

DOI:10.22159/ijpps.2019v11i1.29428

Reference yield: 85.0%

4-hydroxy-3-methoxy-benzoic acid chloride (55828-12-1) → 4-hydroxy-3-methoxybenzoic hydrazide (100377-63-7)

Guidance literature:

With potassium hydroxide; hydrazine;

DOI:10.1007/s11094-021-02439-4

upstream raw materials:

3-methoxy-4-acetoxybenzoyl chloride

ethyl vanillate

3-methoxy-4-hydroxybenzoic acid

4-hydroxy-3-methoxybenzoic acid methyl ester

Downstream raw materials:

2-methoxy-4-[1,3,4]oxadiazol-2-yl-phenol

C₁₂H₁₅N₃O₃S

C₁₃H₁₂N₂O₄

C₁₃H₁₂N₂O₃S

Refernces

• 1、 Dasan, Neethu,Babu,George, Shiny. "Molecular docking studies and synthesis of 3, 4-disubstituted triazoles as mycobacterium tuberculosis enoyl-acp reductase and CYP-51 inhibitors". . p. 85 - 91. Retrieved 2019.
• 2、 Mai, Hengtang,Wang, Yu,Li, Shuang,Jia, Ruizhen,Li, Sixian,Peng, Qian,Xie, Yan,Hu, Xiang,Wu, Song. "A pH-sensitive near-infrared fluorescent probe with alkaline p: K a for chronic wound monitoring in diabetic mice". . p. 7374 - 7377. Retrieved 2019.
• 3、 Gupta, Nishi,Mukerjee, Alok,Mishra, Shanti Bhushan. "Design, Synthesis and Molecular Docking of Vanillic Acid Derivatives as Amylolytic Enzyme Inhibitors". . p. 427 - 435. Retrieved 2021.
• 4、 Bogdanovi?, Goran A.,Milovanovi?, Vesna M.,Novakovi?, Sla?ana,Petrovi?, Vladimir P.,Petrovi?, Zorica D.,Simijonovi?, Du?ica. "Green synthesis of benzamide-dioxoisoindoline derivatives and assessment of their radical scavenging activity – Experimental and theoretical approach". . . Retrieved 2020/08/19.