N-(tert-butyl)-3-chloropropanamide

Base Information

• Chemical Name: N-(tert-butyl)-3-chloropropanamide
• CAS No.: 100859-81-2
• Molecular Formula: C7H14ClNO
• Molecular Weight: 163.647
• Hs Code.: 2924199090
• Mol file: 100859-81-2.mol

Synonyms:ClCH2CONH Bu;3-Chlor-propionsaeure-tert-butylamid;N-t-butyl-3-chloropropionamide;N-tert-Butyl-3-chlor-propionamid;N-t-butyl-3-chloropropanamide;3-chloro-propionic acid tert-butylamide;

Chemical Property of N-(tert-butyl)-3-chloropropanamide

Chemical Property:

• Vapor Pressure: 0.00445mmHg at 25°C
• Boiling Point: 277.7oC at 760 mmHg
• Flash Point: 121.8oC
• PSA: 29.10000
• Density: 1.013g/cm3
• LogP: 1.92090

Purity/Quality:

98%min ^*data from raw suppliers

N-(tert-Butyl)-3-chloropropanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(tert-butyl)-3-chloropropanamide

There total 4 articles about N-(tert-butyl)-3-chloropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butylamine (75-64-9) + 2-chloropropionyl chloride (625-36-5) → N-tert-butyl-2-(chloromethyl)acetamide (100859-81-2)

Guidance literature:

With sodium hydroxide; In dichloromethane; water; at -20 - 20 ℃; for 2h;

Reference yield: 95.0%

3-Chloropropionitrile (542-76-7) + acetic acid tert-butyl ester (540-88-5) → N-tert-butyl-2-(chloromethyl)acetamide (100859-81-2)

Guidance literature:

With Polyvinylpolypyrrolidone-Supported Boron Trifluoride (PVPP-BF₃); In 1,2-dichloro-ethane; at 70 ℃; for 3h;

DOI:10.1155/2012/632574

Reference yield: 91.0%

3-Chloropropionitrile (542-76-7) + tert-butyl alcohol (75-65-0) → N-tert-butyl-2-(chloromethyl)acetamide (100859-81-2)

Guidance literature:

With sulfuric acid; In neat (no solvent); at 20 ℃; for 0.5h; Milling;

DOI:10.1002/ejoc.201500051

upstream raw materials:

tert-butylamine

2-chloropropionyl chloride

propionic acid

3-Chloropropionitrile

Downstream raw materials:

4-benzoyloxy-1-t-butylazetidin-2-one

Refernces

• 1、 Mokhtary, Masoud,Najafizadeh, Faranak. "Polyvinylpolypyrrolidone-supported boron trifluoride; Highly efficient catalyst for the synthesis of N-tert-butyl amides". experimental part. p. 576 - 582. Retrieved 2012/06/30.
• 2、 Deshmukh, A. R. A. S.,Gumaste, V. K.,Bhawal, B. M.. "Rare earth exchanged HY zeolite, an efficient catalyst for the synthesis of N-monosubstituted amides". . p. 369 - 371. Retrieved 2007/10/03.