Pyridine, 2-chloro-4,6-dimethyl-3,5-diphenyl-

Base Information

• Chemical Name: Pyridine, 2-chloro-4,6-dimethyl-3,5-diphenyl-
• CAS No.: 101868-36-4
• Molecular Formula: C19H16ClN
• Molecular Weight: 293.796
• Mol file: 101868-36-4.mol

Synonyms:

Chemical Property of Pyridine, 2-chloro-4,6-dimethyl-3,5-diphenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 2-chloro-4,6-dimethyl-3,5-diphenyl-

There total 6 articles about Pyridine, 2-chloro-4,6-dimethyl-3,5-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3,5-dibromo-2-chloro-4,6-dimethylpyridine (915946-47-3) + phenylboronic acid (98-80-6) → 2-chloro-4,6-dimethyl-3,5-diphenylpyridine (101868-36-4)

Guidance literature:

With palladium diacetate; sodium carbonate; tris-(o-tolyl)phosphine; In ethanol; water; toluene; at 85 ℃; for 8h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;

DOI:10.3998/ark.5550190.p009.772

Reference yield: 85.0%

3,5-dibromo-2-chloro-4,6-dimethylpyridine (915946-47-3) + phenylboronic acid (98-80-6) → 2-chloro-4,6-dimethyl-3,5-diphenylpyridine (101868-36-4) + 2,4-dimethyl-3,5,6-triphenylpyridine (79999-01-2)

Guidance literature:

With potassium phosphate; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate; In toluene; at 90 ℃; for 1h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;

DOI:10.3998/ark.5550190.p009.772

Reference yield:

3,5-dibromo-2-chloro-4,6-dimethylpyridine (915946-47-3) + phenylboronic acid (98-80-6) → 2-chloro-4,6-dimethyl-pyridine (30838-93-8) + 2,4-dimethyl-3,5-diphenylpyridine (66592-70-9) + 2-chloro-4,6-dimethyl-3,5-diphenylpyridine (101868-36-4) + 2,4-dimethyl-3,5,6-triphenylpyridine (79999-01-2)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 105 ℃; for 8h; Title compound not separated from byproducts.;

DOI:10.1055/s-2006-942535

upstream raw materials:

4,6-dimethyl-3,5-diphenyl-pyridin-2-ol

3,5-dibromo-2-chloro-4,6-dimethylpyridine

phenylboronic acid

3-oxo-2-phenylbutanamide

Downstream raw materials:

2,4-dimethyl-3,5-diphenylpyridine

Refernces

• 1、 Blachut, Dariusz,Czarnocki, Zbigniew,Wojtasiewicz, Krystyna. "A Suzuki-Miyaura approach to a series of forensically relevant pyridines". . p. 2855 - 2864. Retrieved 2008/02/07.