2-Piperidin-1-yl-cyclohexanol

Base Information

• Chemical Name: 2-Piperidin-1-yl-cyclohexanol
• CAS No.: 7581-94-4
• Molecular Formula: C11H21 N O
• Molecular Weight: 183.294
• European Community (EC) Number: 231-485-9
• ChEMBL ID: CHEMBL278137
• Mol file: 7581-94-4.mol

Synonyms:2-Piperidin-1-yl-cyclohexanol;7581-94-4;2-piperidin-1-ylcyclohexan-1-ol;CHEMBL278137;2-(1-piperidinyl)cyclohexanol;SCHEMBL6593610;2-(Piperidin-1-yl)cyclohexanol;2-(piperidin-1-yl) cyclohexanol;UXCABTUQGBBPPF-UHFFFAOYSA-N;1-(2-Hydroxycyclohexyl)piperidine;BDBM50018073;AKOS009123732

Chemical Property of 2-Piperidin-1-yl-cyclohexanol

Chemical Property:

• Vapor Pressure: 0.000421mmHg at 25°C
• Boiling Point: 281.5°C at 760 mmHg
• Flash Point: 79.8°C
• PSA: 23.47000
• Density: 1.049g/cm³
• LogP: 1.71370
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 183.162314293
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

99% ^*data from raw suppliers

trans-2-(piperidin-1-yl)cyclohexanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C2CCCCC2O

Technology Process of 2-Piperidin-1-yl-cyclohexanol

There total 19 articles about 2-Piperidin-1-yl-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

piperidine (110-89-4) + cyclohexane-1,2-epoxide (286-20-4) → trans-2-(pipoeridin-1-yl)cyclohexanol (7581-94-4)

Guidance literature:

With zirconium(IV) chloride; at 20 ℃; for 0.25h;

DOI:10.1016/j.tetlet.2003.09.046

Reference yield: 94.0%

piperidine (110-89-4) + cyclohexane-1,2-epoxide (286-20-4) → (+)-trans-(1-Piperidyl)cyclohexan-2-ol (7581-94-4,7583-84-8,69420-69-5,87593-62-2,147528-44-7)

Guidance literature:

1,3-bis(3,5-bis(trifluoro-ethyl)phenyl)thiourea; In water; at 40 ℃;

DOI:10.1039/b605850g

Reference yield: 92.0%

pyridine (110-86-1) + cyclohexane-1,2-epoxide (286-20-4) → trans-2-(pipoeridin-1-yl)cyclohexanol (7581-94-4)

Guidance literature:

scandium tris(trifluoromethanesulfonate); at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2005.10.106

upstream raw materials:

piperidine

cyclohexane-1,2-epoxide

pyridine

2-iodo-1-cyclohexanol

Downstream raw materials:

(+/-)-trans-2-(piperidin-1-yl)cyclohexanamine

Refernces

• 1、 Du, Jun,Zhou, Shuangliu,Zhang, Xiuli,Zhang, Lijun,Cui, Peng,Huang, Zeming,Wei, Yun,Zhu, Xiancui,Wang, Shaowu. "Syntheses, structures and catalytic activities of low-coordinated rare-earth metal complexes containing 2,2′-pyridylpyrrolides". . . Retrieved 2019/11/20.
• 2、 Kumar, Sushil,Gupta, Rajeev. "Heterogeneous ring-opening reactions and Knoevenagel condensation reactions with cobalt complexes: Effect of CoII versus CoIII states on catalysis". . p. 843 - 852. Retrieved 2020/06/26.