Cyclohexaneacetic acid, a-methoxy-, methyl ester

Base Information

• Chemical Name: Cyclohexaneacetic acid, a-methoxy-, methyl ester
• CAS No.: 104036-61-5
• Molecular Formula: C10H18O3
• Molecular Weight: 186.24800
• Mol file: 104036-61-5.mol

Synonyms:Cyclohexyl-methoxy-essigsaeure-methylester;

Chemical Property of Cyclohexaneacetic acid, a-methoxy-, methyl ester

Chemical Property:

• Boiling Point: 120 °C(Press: 30 Torr)
• PSA: 35.53000
• Density: 1.007±0.06 g/cm3(Predicted)
• LogP: 1.75470

Purity/Quality:

Methyl2-cyclohexyl-2-methoxyacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexaneacetic acid, a-methoxy-, methyl ester

There total 4 articles about Cyclohexaneacetic acid, a-methoxy-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

methanol (67-56-1) + (1-Methoxy-allyl)-cyclohexane (136803-10-6) → cyclohexyl-methoxy-acetic acid methyl ester (104036-61-5)

Guidance literature:

With sodium hydroxide; ozone; In dichloromethane; at -78 ℃;

DOI:10.1021/jo00066a019

Reference yield: 5.0%

rac-methoxyphenylacetic acid (7021-09-2) → methyl cyclohexylacetate (14352-61-5) + cyclohexyl-methoxy-acetic acid methyl ester (104036-61-5)

Guidance literature:

With methanol; rhodium(III) chloride; for 24h; under 760 Torr; Ambient temperature;

DOI:10.1016/S0040-4039(00)82035-3

Reference yield:

methanol (67-56-1) + rac-methoxyphenylacetic acid (7021-09-2) → methyl cyclohexylacetate (14352-61-5) + cyclohexyl-methoxy-acetic acid methyl ester (104036-61-5)

Guidance literature:

With hydrogen; 1,5-hexadienerhodium(I)-chloride dimer; for 24h; under 760 Torr; Product distribution; Ambient temperature; effect of <1,5-HDRhCl>2 and RhCl3;

DOI:10.1016/S0040-4039(00)82035-3

upstream raw materials:

methanol

rac-methoxyphenylacetic acid

(1-Methoxy-allyl)-cyclohexane

methyl iodide

Refernces

• 1、 Lin, Ivan J. B.,Zahalka, Hayder A.,Alper, Howard. "RHODIUM CATALYZED REDUCTIVE ESTERIFICATION REACTIONS". . p. 1759 - 1762. Retrieved 2007/10/02.