Ethyl 4,7-dihydro-7-oxopyrazolo[1,5-a]pyrimidine-3-carboxylate

Base Information

• Chemical Name: Ethyl 4,7-dihydro-7-oxopyrazolo[1,5-a]pyrimidine-3-carboxylate
• CAS No.: 104556-86-7
• Molecular Formula: C9H9N3O3
• Molecular Weight: 207.18600
• Hs Code.: 2933990090
• Mol file: 104556-86-7.mol

Synonyms:3-ethoxycarbonyl-propionyl chloride;Ethyl succinyl chloride(ESC);ETHYL 4-CHLORO-4-OXOBUTYRATE;ETHYLSS-BENZOYLACRYLATE;ethyl 3-(chlorocarbonyl)propanoate;Ethyl succinyl chloride;3-carboethoxy-propionyl chloride;Monoethyl succinyl chloride;Ethyl succinoyl chloride;3-Carbethoxypropionyl chloride;3-chlorocarbonyl-propionic acid ethyl ester;ethyl 4-chloro-4-oxobutanoate;Ethyl siccinyl chloride;3-ethoxycarbonylpyrazolo<1,5-a>pyrimidin-7-one;ethyl 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate;

Chemical Property of Ethyl 4,7-dihydro-7-oxopyrazolo[1,5-a]pyrimidine-3-carboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 377.203oC at 760 mmHg
• Flash Point: 181.926oC
• PSA: 76.46000
• Density: 1.471g/cm3
• LogP: 0.19930
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

Ethyl 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4,7-dihydro-7-oxopyrazolo[1,5-a]pyrimidine-3-carboxylate

There total 2 articles about Ethyl 4,7-dihydro-7-oxopyrazolo[1,5-a]pyrimidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl acetate (141-78-6) + ethyl 5-amino-1H-pyrazole-4-carboxylate (1260243-04-6,6994-25-8) + formic acid ethyl ester (109-94-4) → 3-ethoxycarbonylpyrazolo<1,5-a>pyrimidin-7-one (104556-86-7)

Guidance literature:

ethyl acetate; formic acid ethyl ester; With sodium; In ethanol; toluene; at 20 ℃; for 16h;

ethyl 5-amino-1H-pyrazole-4-carboxylate; In ethanol; toluene; at 80 ℃; for 4h; Further stages.;

DOI:10.1021/jo062120g

Reference yield: 34.0%

1,3-dimethyluracil (874-14-6,156398-76-4) + 3-amino-4-pyrazolecarboxylic acid ethyl ester (6994-25-8,103259-35-4,19750-02-8) → 3-ethoxycarbonylpyrazolo<1,5-a>pyrimidin-7-one (104556-86-7)

Guidance literature:

With sodium ethanolate; acetic acid; In ethanol; at 85 - 90 ℃; for 1h;

DOI:10.1002/jhet.5570230209

upstream raw materials:

1,3-dimethyluracil

3-amino-4-pyrazolecarboxylic acid ethyl ester

ethyl acetate

ethyl 5-amino-1H-pyrazole-4-carboxylate

Refernces

• 1、 Chu,Suh,Mesbah,Cutler. "Ring transformation reactions of C-nucleosides: Facile synthesis of pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5- a]triazine C-nucleosides". . p. 349 - 352. Retrieved 2007/10/02.