7S-NERVE GROWTH FACTOR, MOUSE

Base Information

• Chemical Name: 7S-NERVE GROWTH FACTOR, MOUSE
• CAS No.: 9061-61-4
• Molecular Weight: 0
• Mol file: 9061-61-4.mol

Synonyms:NGF; Nervegrowth hormone

Chemical Property of 7S-NERVE GROWTH FACTOR, MOUSE

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: −20°C

Purity/Quality:

99%, ^*data from raw suppliers

NGF ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Biological functions: Both TrkA and p75NTR are expressed in sensory neurons, sympathetic neurons, and cholinergic neurons. The activation of TrkA induces the survival of these neurons, promotes outgrowth of the neurite, and stimulates the synthesis of neurotransmitters. The involvement of p75NTR in apoptosis is observed in the avian retina, mouse basal forebrain, and rat cerebral cortex. p75NTR-mediated apoptosis of the rat oligodendrocytes is induced specifically by NGF but not by other neurotrophins.
• Description: NGF is the first member of the neurotrophin-family trophic factors. NGF regulates the growth, maintenance, proliferation, and survival of certain target neurons through activation of the high affinity receptor, tropomyosin receptor kinase A (TrkA). NGF is also involved in apoptosis through binding to the low affinity receptor, p75NTR. NGF consists of three types of subunits, α, β, and γ, and the β-subunit is solely responsible for the nerve growth stimulating activity of NGF.
• Clinical Use: NGF is now known to have therapeutic potential on peripheral and central nervous system diseases but also on the visual system, cutaneous wound healing, and the regulation of immune system functions. NGF shows protective effects on cholinergic neurons in the brains of Alzheimer’s disease model animals. NGF also shows promoting effects on neurite outgrowth in the aged human and rat.