sudoxicam

Base Information

• Chemical Name: sudoxicam
• CAS No.: 34042-85-8
• Molecular Formula: C13H11N3O4S2
• Molecular Weight: 337.38
• Mol file: 34042-85-8.mol

Synonyms:N-(2-thiazolyl)-4-hydroxy-2-methyl-2H,1,2-benzothiazine-3-carboxamide 1,1-dioxide;4-hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide;Sudoxicamum;SUDOXICAM;4-hydroxy-2-methyl-N-(2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide;Sudoxicamum [INN-Latin];EINECS 251-808-7;2H-1,2-Benzothiazine-3-carboxamide,4-hydroxy-2-methyl-N-2-thiazolyl-,1,1-dioxide;

Chemical Property of sudoxicam

Chemical Property:

• Melting Point: 240-243°C (dec.)
• PSA: 136.22000
• Density: 1.675g/cm³
• LogP: 2.73420
• Storage Temp.: Refrigerator

Purity/Quality:

98%Min ^*data from raw suppliers

Sudoxicam ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Sudoxicam and Meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs) from the enol-carboxamide class.

Technology Process of sudoxicam

There total 5 articles about sudoxicam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide (6639-62-9) → sudoxicam (34042-85-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 25percent MeONa/MeOH / toluene / 4 h / 80 °C

2: 1M aq.NaOH / ethanol / 24 h / Ambient temperature

3: xylene / 48 h / Heating

With methanol; sodium hydroxide; sodium methylate; In ethanol; toluene; xylene;

DOI:10.1021/jm9607010

Reference yield:

methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (35511-14-9) → sudoxicam (34042-85-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1M aq.NaOH / ethanol / 24 h / Ambient temperature

2: xylene / 48 h / Heating

With sodium hydroxide; In ethanol; xylene;

DOI:10.1021/jm9607010

Reference yield:

saccharin (81-07-2) → sudoxicam (34042-85-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 50 deg C, 30 min, 2.) DMF, 4 h

2: 25percent MeONa/MeOH / toluene / 4 h / 80 °C

3: 1M aq.NaOH / ethanol / 24 h / Ambient temperature

4: xylene / 48 h / Heating

With methanol; sodium hydroxide; sodium methylate; sodium hydride; In ethanol; toluene; xylene;

DOI:10.1021/jm9607010

upstream raw materials:

2-thiazolylamine

methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide

methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

Refernces

• 1、 Lazer, Edward S.,Miao, Clara K.,Cywin, Charles L.,Sorcek, Ronald,Wong, Hin-Chor,Meng, Zhaoxing,Potocki, Ian,Hoermann, MaryAnn,Snow, Roger J.,Tschantz, Matt A.,Kelly, Terence A.,McNeil, Daniel W.,Coutts, Simon J.,Churchill, Laurie,Graham, Anne G.,David, Eva,Grob, Peter M.,Engel, Wolfhard,Meier, Hans,Trummlitz, Günter. "Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity". . p. 980 - 989. Retrieved 2007/10/03.
• 2、 -. "Pharmaceutical preparation for the therapeutic treatment of rheumatic diseases". . . Retrieved 2008/06/13.