2,5-bis(benzyloxy)aniline

Base Information

• Chemical Name: 2,5-bis(benzyloxy)aniline
• CAS No.: 51792-84-8
• Molecular Formula: C20H19 N O2
• Molecular Weight: 305.376
• Mol file: 51792-84-8.mol

Synonyms:Aniline,2,5-bis(benzyloxy)- (3CI); NSC 65364

Chemical Property of 2,5-bis(benzyloxy)aniline

Chemical Property:

• Vapor Pressure: 7.38E-10mmHg at 25°C
• Boiling Point: 492.9°Cat760mmHg
• Flash Point: 279.5°C
• Density: 1.169g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-bis(benzyloxy)aniline

There total 4 articles about 2,5-bis(benzyloxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

(((2-nitro-1,4-phenylene)bis(oxy))bis(methylene))dibenzene (51792-85-9) → 2,5-bis(benzyloxy)aniline (51792-84-8)

Guidance literature:

With hydrogen; nickel; In ethyl acetate; at 23 ℃; for 3h; under 75.006 Torr;

DOI:10.1002/hlca.19820650835

Reference yield:

→ 2,5-bis(benzyloxy)aniline (51792-84-8)

Guidance literature:

With ethanol; at 90 ℃; under 110326 Torr; Hydrogenation;

Reference yield:

1,4-dibenzyloxybenzene (621-91-0) → 2,5-bis(benzyloxy)aniline (51792-84-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93.9 percent / HNO₃ / acetic acid / 0.5 h / 30 °C

2: 97.6 percent / H₂ / Raney-Ni / ethyl acetate / 3 h / 23 °C / 75.01 Torr

With hydrogen; nitric acid; nickel; In acetic acid; ethyl acetate;

DOI:10.1002/hlca.19820650835

upstream raw materials:

(((2-nitro-1,4-phenylene)bis(oxy))bis(methylene))dibenzene

1,4-dibenzyloxybenzene

Downstream raw materials:

acetic acid-(2,5-bis-benzyloxy-anilide)

3-<<2,5-Bis(benzyloxy)phenyl>amino>-5,5-dimethyl-2-cyclohexen-1-on

1-Aethyl-6-(4-nitroanilino)-4,5,8-trioxo-1,4,5,8-tetrahydro-3-chinolincarbonsaeure

1-Aethyl-4,5,8-trioxo-6-(3,4,5-trimethoxyanilino)-1,4,5,8-tetrahydro-3-chinolincarbonsaeure

Refernces

• 1、 Link, Helmut,Bernauer, Karl,Englert, Gerhard. "Abkoemmlinge der 3-Chinolincarbonsaeure mit Sauerstoffsubstitution in Stellung 4,5 und 8: Synthese, Reaktionen, NMR-Studien". . p. 2645 - 2667. Retrieved 2007/10/02.