2-Naphthalenepropanoic acid, a-methyl-

Base Information

• Chemical Name: 2-Naphthalenepropanoic acid, a-methyl-
• CAS No.: 107777-19-5
• Molecular Formula: C14H14O2
• Molecular Weight: 214.26000
• Mol file: 107777-19-5.mol

Synonyms:.2-Methyl-3-[2]naphthyl-propionsaeure;.(+/-)-2-Methyl-3-[2]naphthyl-propionsaeure;.(+/-)-2-methyl-3-[2]naphthyl-propionic acid;2-methyl-3-(2-naphthyl)propionic acid;.2-methyl-3-[2]naphthyl-propionic acid;

Chemical Property of 2-Naphthalenepropanoic acid, a-methyl-

Chemical Property:

• Melting Point: 90 °C
• Boiling Point: 385.3±11.0 °C(Predicted)
• PSA: 37.30000
• Density: 1.162±0.06 g/cm3(Predicted)
• LogP: 3.10300

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Naphthalenepropanoic acid, a-methyl-

There total 1 articles about 2-Naphthalenepropanoic acid, a-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-allylnaphthalene (2489-87-4) + benzene-1,3,5-triyl triformate → 4-(2-naphthyl)butyric acid (782-28-5) + 2-(naphthalen-2-yl)butanoic acid (15410-83-0) + 2-methyl-3-naphthalen-2-ylpropionic acid (107777-19-5)

Guidance literature:

With formic acid; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 100 ℃; Overall yield = 67 %; Overall yield = 45.7 mg; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b02047

Reference yield: 98.0%

2-methyl-3-naphthalen-2-ylpropionic acid (107777-19-5) → 2-methyl-2,3-dihydro-cyclopenta[a]naphthalen-1-one (150096-57-4,641626-75-7)

Guidance literature:

2-methyl-3-naphthalen-2-ylpropionic acid; With phosphorus pentachloride; In toluene; at 20 ℃; for 1h;

With tin(IV) chloride; In toluene; at 20 ℃; for 13h;

DOI:10.1002/ejoc.200500322

Reference yield: 77.0%

methyl hydroxy(phenyl)carbamodithioate (1013632-21-7) + 2-methyl-3-naphthalen-2-ylpropionic acid (107777-19-5) → methyl 2-methyl-3-(naphthalen-2-yl)propanoyloxy(phenyl)carbamodithioate (1013632-24-0)

Guidance literature:

2-methyl-3-naphthalen-2-ylpropionic acid; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃;

methyl hydroxy(phenyl)carbamodithioate; In dichloromethane; at 0 - 20 ℃; Darkness;

DOI:10.1021/ol702832x

upstream raw materials:

2-allylnaphthalene

Downstream raw materials:

2-methyl-2,3-dihydro-cyclopenta[a]naphthalen-1-one

(S)-(-)-2-methyl-2,3-dihydro-1H-benz[e]inden-1-one

(R)-(-)-2-methyl-2,3-dihydro-1H-benz[e]inden-1-one

methyl 2-methyl-3-(naphthalen-2-yl)propanoyloxy(phenyl)carbamodithioate

Refernces