1,4-DIACETYL-2-METHYLIMIDAZOLE

Base Information

• Chemical Name: 1,4-DIACETYL-2-METHYLIMIDAZOLE
• CAS No.: 108512-13-6
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.17700
• Hs Code.: 2933290090
• Mol file: 108512-13-6.mol

Synonyms:1,4-DIACETYL-2-METHYLIMIDAZOLE;1H-Imidazole,1,4-diacetyl-2-methyl;

Chemical Property of 1,4-DIACETYL-2-METHYLIMIDAZOLE

Chemical Property:

• Vapor Pressure: 0.000235mmHg at 25°C
• Boiling Point: 325.1oC at 760 mmHg
• Flash Point: 150.4oC
• PSA: 51.96000
• Density: 1.18g/cm3
• LogP: 1.05420

Purity/Quality:

99%min ^*data from raw suppliers

1,4-DIACETYL-2-METHYLIMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-DIACETYL-2-METHYLIMIDAZOLE

There total 3 articles about 1,4-DIACETYL-2-METHYLIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4(5)-acetyl-2-methyl-1H-imidazole (78210-66-9) + acetyl chloride (75-36-5) → 1,4-diacetyl-2-methylimidazole (108512-13-6)

Guidance literature:

With TEA; In chloroform; for 4.5h;

DOI:10.1021/jo00389a015

Reference yield:

N-(5-methyl-4-isoxazolyl)acetamide (100499-63-6) → 1,4-diacetyl-2-methylimidazole (108512-13-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / H₂ / 10percent Pd on C / methanol / 1 h / 2327.2 Torr / Ambient temperature

2: NaOH / ethanol / 1 h / Heating

3: 71 percent / TEA / CHCl₃ / 4.5 h

With sodium hydroxide; TEA; hydrogen; palladium on activated charcoal; In methanol; ethanol; chloroform;

DOI:10.1021/jo00389a015

Reference yield:

3-acetamido-4-amino-3-buten-2-one (100499-65-8) → 1,4-diacetyl-2-methylimidazole (108512-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / ethanol / 1 h / Heating

2: 71 percent / TEA / CHCl₃ / 4.5 h

With sodium hydroxide; TEA; In ethanol; chloroform;

DOI:10.1021/jo00389a015

upstream raw materials:

4⁽⁵⁾-acetyl-2-methyl-1H-imidazole

acetyl chloride

N-(5-methyl-4-isoxazolyl)acetamide

3-acetamido-4-amino-3-buten-2-one

Downstream raw materials:

5-acetyl-1,2-dimethylimidazole

Refernces