Benzeneacetic acid, a-phenyl-a-propoxy-, 4-piperidinyl ester, hydrochloride

Base Information

• Chemical Name: Benzeneacetic acid, a-phenyl-a-propoxy-, 4-piperidinyl ester, hydrochloride
• CAS No.: 108640-64-8
• Molecular Formula: C22H27NO3.ClH
• Molecular Weight: 389.922
• Mol file: 108640-64-8.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-phenyl-a-propoxy-, 4-piperidinyl ester, hydrochloride

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, a-phenyl-a-propoxy-, 4-piperidinyl ester, hydrochloride

There total 6 articles about Benzeneacetic acid, a-phenyl-a-propoxy-, 4-piperidinyl ester, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

Diphenyl(1-propoxy)essigsaeure(1'-benzylpiperid-4'-yl)-esterhydrochlorid (118108-63-7) → Diphenyl(1-propoxy)essigsaeure-piperid-4'-yl-esterhydrochlorid (108640-64-8)

Guidance literature:

With hydrogen; nickel; In methanol; acetic acid; at 30 ℃; for 96h;

Reference yield:

1-benzylpiperidin-4-yl 2-hydroxy-2,2-diphenylacetate (118108-61-5) → Diphenyl(1-propoxy)essigsaeure-piperid-4'-yl-esterhydrochlorid (108640-64-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / H₂ / 10 percent Pd/C / methanol; acetic acid / 4 h / 30 °C

2: SOCl₂, DMF / chlorobenzene / 10 h / 90 - 95 °C

3: 8 h / Heating

With thionyl chloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; acetic acid; chlorobenzene;

Reference yield:

methyl benzilate (76-89-1) → Diphenyl(1-propoxy)essigsaeure-piperid-4'-yl-esterhydrochlorid (108640-64-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 67.6 percent / 10 percent CH₃ONa / petroleum ether; methanol / 4.5 h / Heating

2: 93 percent / H₂ / 10 percent Pd/C / methanol; acetic acid / 4 h / 30 °C

3: SOCl₂, DMF / chlorobenzene / 10 h / 90 - 95 °C

4: 8 h / Heating

With thionyl chloride; hydrogen; sodium methylate; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; acetic acid; chlorobenzene; Petroleum ether;

upstream raw materials:

propan-1-ol

Diphenyl(1-propoxy)essigsaeure(1'-benzylpiperid-4'-yl)-esterhydrochlorid

1-benzylpiperidin-4-yl 2-hydroxy-2,2-diphenylacetate

methyl benzilate

Refernces