2-[2-(2-Methoxyethoxy)ethoxy]acetic acid

Base Information

• Chemical Name: 2-[2-(2-Methoxyethoxy)ethoxy]acetic acid
• CAS No.: 16024-58-1
• Molecular Formula: C7H14O5
• Molecular Weight: 178.185
• Hs Code.: 2918 99 90
• European Community (EC) Number: 240-162-1
• UNII: PHF784H2CZ
• DSSTox Substance ID: DTXSID4075401
• Nikkaji Number: J219.942D
• Wikidata: Q72489753
• Mol file: 16024-58-1.mol

Synonyms:16024-58-1;2-[2-(2-Methoxyethoxy)ethoxy]acetic acid;2-(2-(2-methoxyethoxy)ethoxy)acetic acid;3,6,9-trioxadecanoic acid;[2-(2-methoxyethoxy)ethoxy]acetic acid;mPEG2-CH2COOH;Acetic acid, [2-(2-methoxyethoxy)ethoxy]-;(2-(2-Methoxyethoxy)ethoxy)acetic acid;PHF784H2CZ;2-[2-(2-methoxyethoxy)ethoxy]ethanoic acid;Acetic acid, (2-(2-methoxyethoxy)ethoxy)-;Acetic acid, 2-(2-(2-methoxyethoxy)ethoxy)-;EINECS 240-162-1;MFCD00044098;2-[2-(2-Methoxyethoxy)ethoxy]acetic acid, tech grade;Acetic acid, 2-[2-(2-methoxyethoxy)ethoxy]-;O-[2-(2-Methoxyethoxy)ethyl]glycolic acid;3,6,9-Trioxadecanoic Acid;2-(2-(2-methoxyethoxy)ethoxy)aceticacid;2-[2-(2-METHOXYETHOXY)ETHOXY]ACETICACID;2-(2-(2-methoxyethoxy)ethoxy) acetic acid;8-Methoxy-3,6-dioxaoctanoic acid;UNII-PHF784H2CZ;SCHEMBL102373;DTXSID4075401;STL490749;2-(2-methoxyethoxy)ethoxyacetic acid;AKOS015892768;AS-77227;SY033787;2-(2-(2-methoxyethoxyl)ethoxy)acetic acid;[2-(2-methoxy-ethoxy)-ethoxy]-acetic acid;CS-0046435;FT-0637306;M2963;2-[2-(2-methoxy-ethoxy)ethoxy]-acetic acid;D95266;EN300-7413870;A810126;[(2-{[2-(methyloxy)ethyl]oxy}ethyl)oxy]acetic acid;2-[2-(2-Methoxyethoxy)ethoxy]acetic acid, technical grade;2-[2-(2-Methoxyethoxy)ethoxy]acetic acid, technical, >=90% (GC)

Chemical Property of 2-[2-(2-Methoxyethoxy)ethoxy]acetic acid

Chemical Property:

• Appearance/Colour: COA
• Vapor Pressure: 0.000376mmHg at 25°C
• Refractive Index: n20/D 1.446(lit.)
• Boiling Point: 295.214 °C at 760 mmHg
• PKA: 3.39±0.10(Predicted)
• Flash Point: 116.711 °C
• PSA: 64.99000
• Density: 1.129 g/cm³
• LogP: -0.24940
• Storage Temp.: Store below +30°C.
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 178.08412354
• Heavy Atom Count: 12
• Complexity: 114

Purity/Quality:

99% ^*data from raw suppliers

2-[2-(2-Methoxyethoxy)ethoxy]acetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xi
• Statements: 34-41
• Safety Statements: 26-36/37/39-45-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COCCOCCOCC(=O)O

Technology Process of 2-[2-(2-Methoxyethoxy)ethoxy]acetic acid

There total 9 articles about 2-[2-(2-Methoxyethoxy)ethoxy]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

triethylene glucol monomethyl ether (112-35-6,95507-80-5) → 2-[2-(2-methoxyethoxy)etoxy]acetic acid (16024-58-1)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; sodium carbonate; at 20 ℃; Electrochemical reaction;

DOI:10.1055/s-2007-991070

Reference yield:

p-nitrophenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate (1252661-82-7) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 2-[2-(2-methoxyethoxy)etoxy]acetic acid (16024-58-1)

Guidance literature:

With 6-{N-[6-(6-deoxy-α-cyclodextrinylthio)acetyl]-L-histidylamino}-6-deoxy-β-cyclodextrin; at 25 ℃; pH=7.4; Kinetics; aq. phosphate buffer;

DOI:10.1016/j.molcata.2010.06.005

Reference yield:

m-nitrophenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate (1252661-81-6) → 2-[2-(2-methoxyethoxy)etoxy]acetic acid (16024-58-1) + meta-nitrophenol (554-84-7)

Guidance literature:

With 6-{N-[6-(6-deoxy-α-cyclodextrinylthio)acetyl]-L-histidylamino}-6-deoxy-β-cyclodextrin; at 25 ℃; pH=7.4; Kinetics; aq. phosphate buffer;

DOI:10.1016/j.molcata.2010.06.005

upstream raw materials:

triethylene glucol monomethyl ether

chloroacetic acid

bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]acetoxy}ethoxy)ethoxy]ethyl ester

p-nitrophenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate

Downstream raw materials:

2-(2-(2-methoxyethoxy)ethoxy)acetyl chloride

4-(benzyl-{2-[(2,5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl}-carbamoyl)-2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-butyric acid methyl ester

2-(4-methoxybenzyl)-5-{2-[2-(2-methoxyethoxy)ethoxy]acetylamino}-2H-pyrazole-3-carboxylic acid methyl ester

(Pd(C₆H₃(O(CH₂)9CH₃)CHNC₆H₄O(CH₂)9CH₃)OCOCH₂O(CH₂CH₂O)2CH₃)2

Refernces

• 1、 -. "Preparation and application of monodisperse polyethylene glycol monomethyl ether modified propofol prodrug". Paragraph 0042-0045. . Retrieved 2018/07/06.
• 2、 Malineni, Jagadeesh,Keul, Helmut,M?ller, Martin. "A green and sustainable phosphine-free NHC-ruthenium catalyst for selective oxidation of alcohols to carboxylic acids in water". supporting information. p. 17409 - 17414. Retrieved 2015/10/12.