2-CYANO-6-METHOXYNAPHTHALENE

Base Information

• Chemical Name: 2-CYANO-6-METHOXYNAPHTHALENE
• CAS No.: 67886-70-8
• Molecular Formula: C12H9NO
• Molecular Weight: 183.21
• Hs Code.: 2926909090
• Mol file: 67886-70-8.mol

Synonyms:2-Naphthonitrile,6-methoxy- (7CI);2-Cyano-6-methoxynaphthalene;6-Methoxy-2-naphthonitrile;6-Methoxynaphthalene-2-carbonitrile;NSC 408778;

Chemical Property of 2-CYANO-6-METHOXYNAPHTHALENE

Chemical Property:

• Vapor Pressure: 5.11E-05mmHg at 25°C
• Melting Point: 106-107 °C(lit.)
• Refractive Index: 1.622
• Boiling Point: 348.2 °C at 760 mmHg
• Flash Point: 146.9 °C
• PSA: 33.02000
• Density: 1.16 g/cm³
• LogP: 2.72008

Purity/Quality:

99% ^*data from raw suppliers

6-Methoxy-2-cyanonaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,T
• Hazard Codes: Xn,T
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 6-Methoxy-2-naphthonitrile (2-cyano-6-methoxynaphthalene) was used in the synthesis of 2-cyano-1-(1,3-diarylpropyl)-6-methoxynaphthalenes.

Technology Process of 2-CYANO-6-METHOXYNAPHTHALENE

There total 22 articles about 2-CYANO-6-METHOXYNAPHTHALENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Bromo-6-methoxynaphthalene (5111-65-9) + copper(I) cyanide (544-92-3) → 2-cyano-6-methoxynaphthalene (67886-70-8)

Guidance literature:

In N,N-dimethyl-formamide; for 4h; Heating;

DOI:10.1021/jm010020r

Reference yield: 99.0%

6-methoxynaphthalene-2-carbaldehyde (3453-33-6) → 2-cyano-6-methoxynaphthalene (67886-70-8)

Guidance literature:

With ammonium sulfate; sodium carbonate; sulfur; In dimethyl sulfoxide; at 120 ℃; for 10h; Sealed tube;

Reference yield: 98.0%

2-Bromo-6-methoxynaphthalene (5111-65-9) → 2-cyano-6-methoxynaphthalene (67886-70-8)

Guidance literature:

With sodium carbonate; palladium diacetate; at 140 ℃; for 16h;

DOI:10.1016/j.jorganchem.2004.08.020

upstream raw materials:

2-Bromo-6-methoxynaphthalene

copper(I) cyanide

N-cyano-benzimidazole

N-cyano-N-phenyl-p-toluenesulfonamide

Downstream raw materials:

1-(6-methoxynaphthalen-2-yl)-2-phenylethanone

(6-methoxynaphthalen-2-yl)(phenyl)methanone

2-methoxy-6-naphthoic acid

6-Hydroxy-2-naphthoic acid

Refernces

• 1、 -. "Method for converting aromatic aldehyde into aromatic nitrile by using sulfur powder promoted inorganic ammonium as nitrogen source (by machine translation)". Paragraph 0072; 0073. . Retrieved 2020/09/12.
• 2、 Yang, Luo,Liu, Yu-Ting,Park, Yoonsu,Park, Sung-Woo,Chang, Sukbok. "Ni-Mediated Generation of "cN" Unit from Formamide and Its Catalysis in the Cyanation Reactions". . p. 3360 - 3365. Retrieved 2019/03/26.