Cyclohexane, 1-azido-1-methoxy-

Base Information

• Chemical Name: Cyclohexane, 1-azido-1-methoxy-
• CAS No.: 111238-46-1
• Molecular Formula: C7H13N3O
• Molecular Weight: 155.2
• Mol file: 111238-46-1.mol

Synonyms:

Chemical Property of Cyclohexane, 1-azido-1-methoxy-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexane, 1-azido-1-methoxy-

There total 2 articles about Cyclohexane, 1-azido-1-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

cycloxexanone dimethyl ketal (933-40-4) → 1-azido-1-methoxycyclohexane (111238-46-1)

Guidance literature:

With tris-(2-chloro-ethyl)-amine; magnesium bromide; In diethyl ether; for 0.166667h; Ambient temperature;

DOI:10.1016/S0040-4039(00)70654-X

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + trimethyl orthoformate (149-73-5) → cycloxexanone dimethyl ketal (933-40-4) + 1-azido-1-methoxycyclohexane (111238-46-1)

Guidance literature:

With hydrogen azide; toluene-4-sulfonic acid; In dichloromethane; for 4h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1021/jo00236a006

Reference yield: 95.0%

1-azido-1-methoxycyclohexane (111238-46-1) → O-methylcaprolactim (2525-16-8)

Guidance literature:

In benzene; for 40h; Irradiation;

DOI:10.1021/jo00236a006

upstream raw materials:

cycloxexanone dimethyl ketal

cyclohexanone

trimethyl orthoformate

Downstream raw materials:

O-methylcaprolactim

Refernces

• 1、 Hassner, Alfred,Fibiger, Richard,Amarasekara, Ananda S.. "TiCl4-Catalyzed Addition of HN3 to Aldehydes and Ketones. Thermolysis and Photolysis of α-Azido Ethers". . p. 22 - 27. Retrieved 2007/10/02.