4',5-Dihydroxy-3',5',7,8-tetramethoxyflavone

Base Information

• Chemical Name: 4',5-Dihydroxy-3',5',7,8-tetramethoxyflavone
• CAS No.: 111670-54-3
• Molecular Formula: C₁₉H₁₈O₈
• Molecular Weight: 374.347
• DSSTox Substance ID: DTXSID001136602
• Mol file: 111670-54-3.mol

Synonyms:4',5-Dihydroxy-3',5',7,8-tetramethoxyflavone;CHEBI:175799;DTXSID001136602;111670-54-3;5-hydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-7,8-dimethoxychromen-4-one;5-Hydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-7,8-dimethoxy-4H-1-benzopyran-4-one

Chemical Property of 4',5-Dihydroxy-3',5',7,8-tetramethoxyflavone

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 374.10016753
• Heavy Atom Count: 27
• Complexity: 550

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1O)OC)C2=CC(=O)C3=C(O2)C(=C(C=C3O)OC)OC

Technology Process of 4',5-Dihydroxy-3',5',7,8-tetramethoxyflavone

There total 3 articles about 4',5-Dihydroxy-3',5',7,8-tetramethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-hydroxy-3,4,6-trimethoxyphenyl)ethanone (7507-98-4) → 5,4'-dihydroxy-7,8,3',5'-tetramethoxyflavone (111670-54-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 2 g / alkali / ethanol

2: 1 g / selenium dioxide / 3-methyl-butan-1-ol / 6 h / Heating

3: 0.5 g / anhydrous AlCl₃ / acetonitrile / 4 h / Heating

With aluminium trichloride; selenium(IV) oxide; In ethanol; i-Amyl alcohol; acetonitrile;

Reference yield:

4-benzyloxy-2,5-dimethyoxybenzaldehyde (76335-85-8) → 5,4'-dihydroxy-7,8,3',5'-tetramethoxyflavone (111670-54-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 2 g / alkali / ethanol

2: 1 g / selenium dioxide / 3-methyl-butan-1-ol / 6 h / Heating

3: 0.5 g / anhydrous AlCl₃ / acetonitrile / 4 h / Heating

With aluminium trichloride; selenium(IV) oxide; In ethanol; i-Amyl alcohol; acetonitrile;

Reference yield:

4-benzyloxy-2'-hydroxy-3',4',6',3,5-pentamethoxychalkone (111670-52-1) → 5,4'-dihydroxy-7,8,3',5'-tetramethoxyflavone (111670-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 g / selenium dioxide / 3-methyl-butan-1-ol / 6 h / Heating

2: 0.5 g / anhydrous AlCl₃ / acetonitrile / 4 h / Heating

With aluminium trichloride; selenium(IV) oxide; In i-Amyl alcohol; acetonitrile;

upstream raw materials:

1-(2-hydroxy-3,4,6-trimethoxyphenyl)ethanone

4-benzyloxy-2,5-dimethyoxybenzaldehyde

4-benzyloxy-2'-hydroxy-3',4',6',3,5-pentamethoxychalkone

Refernces