DIPYRIDO(1,2-a:3',2'-d)IMIDAZOLE

Base Information

• Chemical Name: DIPYRIDO(1,2-a:3',2'-d)IMIDAZOLE
• CAS No.: 245-72-7
• Molecular Formula: C₁₀H₇N₃
• Molecular Weight: 169.186
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30179258
• Nikkaji Number: J76.243A
• Wikidata: Q83049760
• Mol file: 245-72-7.mol

Synonyms:SR08;245-72-7;DIPYRIDO(1,2-a:3',2'-d)IMIDAZOLE;Dipyrido[1,2-a:3',2'-d]imidazole;BRN 0608855;SCHEMBL8860107;DTXSID30179258;AKOS000781751;LS-62945;1,3,8-triazatricyclo[7.4.0.02,7]trideca-2(7),3,5,8,10,12-hexaene

Chemical Property of DIPYRIDO(1,2-a:3',2'-d)IMIDAZOLE

Chemical Property:

• Melting Point: 120-122 °C
• Boiling Point: 284.3±33.0 °C(Predicted)
• PKA: 5.10±0.30(Predicted)
• PSA: 30.19000
• Density: 1.31±0.1 g/cm3(Predicted)
• LogP: 1.88250
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 169.063997236
• Heavy Atom Count: 13
• Complexity: 195

Purity/Quality:

DIPYRIDO[1,2-A:3',2'-D]IMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC3=C(N2C=C1)N=CC=C3

Technology Process of DIPYRIDO(1,2-a:3',2'-d)IMIDAZOLE

There total 20 articles about DIPYRIDO(1,2-a:3',2'-d)IMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-(3-nitropyridin-2-yl)pyridinium chloride (59846-15-0) → pyrido[3',2':4,5]imidazo[1,2-a]pyridine (245-72-7)

Guidance literature:

With tin(ll) chloride; In hydrogenchloride; ethanol; for 0.166667h;

DOI:10.1070/MC2006v016n02ABEH002236

Reference yield: 80.0%

2-aminopyridine (504-29-0) + 2,3-dibromopyridine (13534-89-9) → pyrido[3',2':4,5]imidazo[1,2-a]pyridine (245-72-7) + dipyrido[1,2-a:2',3'-d]imidazole

Guidance literature:

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; copper(l) iodide; In 1,2-dimethoxyethane; at 140 ℃; for 24h;

DOI:10.1021/jo052091u

Reference yield: 60.0%

(propargyl-2)-1 morpholinomethyl-2 imidazo<4,5-b>pyridine (99261-76-4) → C14H17N4O(1+)*HO(1-) + pyrido[3',2':4,5]imidazo[1,2-a]pyridine (245-72-7)

Guidance literature:

In methanol; water; for 7h; Yields of byproduct given; Heating;

DOI:10.1002/jhet.5570220230

upstream raw materials:

4-hydrazinodipyrido<1,2-a:3',2'-d>imidazole

(propargyl-2)-1 morpholinomethyl-2 imidazo<4,5-b>pyridine

glycerol

3-aminoimidazo<1,2-a>pyridine

Refernces

• 1、 Loones, Kristof T.J.,Maes, Bert U.W.,Herrebout, Wouter A.,Dommisse, Roger A.,Lemière, Guy L.F.,Van der Veken, Benjamin J.. "Examination of the mechanism of the intramolecular amination of N-(3-bromopyridin-2-yl)azaheteroarylamines and N-(2-chloropyridin-3-yl)azaheteroarylamines: a Pd-catalyzed amination and/or a base-assisted nucleophilic aromatic substitution?". . p. 3818 - 3825. Retrieved 2007.
• 2、 Begunov, Roman S.,Ryzvanovich, Galina A.,Nozdracheva, Ol'ga I.. "Synthesis of pyrido[3′,2′:4,5]imidazo[1,2-a]pyridines by reductive cyclisation of pyridinium salts". . p. 119 - 120. Retrieved 2006.