Propanoic acid, 2-methyl-, 4-fluorophenyl ester

Base Information

• Chemical Name: Propanoic acid, 2-methyl-, 4-fluorophenyl ester
• CAS No.: 111864-79-0
• Molecular Formula: C₁₀H₁₁FO₂
• Molecular Weight: 182.195
• Mol file: 111864-79-0.mol

Synonyms:2-methylpropanoic acid 4-fluorophenyl ester;4-fluorophenyl isobutyrate;Propanoic acid,2-methyl-,4-fluorophenyl ester;

Chemical Property of Propanoic acid, 2-methyl-, 4-fluorophenyl ester

Chemical Property:

• PSA: 26.30000
• LogP: 2.38710

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanoic acid, 2-methyl-, 4-fluorophenyl ester

There total 2 articles about Propanoic acid, 2-methyl-, 4-fluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-Fluorophenol (371-41-5) + isobutyryl chloride (79-30-1) → 2-methylpropanoic acid 4-fluorophenyl ester (111864-79-0)

Guidance literature:

With triethylamine; In diethyl ether; for 1h; Heating;

Reference yield:

4-Fluorophenol (371-41-5) + 2-Methylpropionic anhydride (97-72-3) → 2-methylpropanoic acid 4-fluorophenyl ester (111864-79-0)

Guidance literature:

With pyridine;

Reference yield: 38.0%

2-methylpropanoic acid 4-fluorophenyl ester (111864-79-0) → 1-(5-Fluoro-2-hydroxy-phenyl)-2-methyl-propan-1-one

Guidance literature:

With aluminium trichloride; at 150 - 180 ℃; for 0.333333h;

upstream raw materials:

4-Fluorophenol

2-Methylpropionic anhydride

isobutyryl chloride

Refernces

• 1、 Schaefer, Ted,Penner, Glenn H.. "The conformational properties of some phenyl esters. Molecular orbital and nuclear magnetic resonance studies". . p. 2175 - 2178. Retrieved 2007/10/02.