Tetrafluorosuccinic acid

Base Information

• Chemical Name: Tetrafluorosuccinic acid
• CAS No.: 377-38-8
• Deprecated CAS: 110961-36-9
• Molecular Formula: C4H2 F4 O4
• Molecular Weight: 190.051
• Hs Code.: 29171900
• European Community (EC) Number: 206-820-7
• NSC Number: 3238
• UNII: IS19QHB8AK
• DSSTox Substance ID: DTXSID8059928
• Nikkaji Number: J54.352G
• Wikidata: Q81985267
• ChEMBL ID: CHEMBL84420
• Mol file: 377-38-8.mol

Synonyms:perfluorosuccinate;perfluorosuccinic acid;perfluorosuccinic acid, ammonia salt;tetrafluorosuccinic acid

Chemical Property of Tetrafluorosuccinic acid

Chemical Property:

• Appearance/Colour: beige crystalline powder
• Vapor Pressure: 0.137mmHg at 25°C
• Melting Point: 115-118 °C(lit.)
• Boiling Point: 200.3 °C at 760 mmHg
• PKA: -1.03±0.28(Predicted)
• Flash Point: 75 °C
• PSA: 74.60000
• Density: 1.797 g/cm³
• LogP: 0.42620
• Water Solubility.: almost transparency in Water
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 3
• Exact Mass: 189.98892119
• Heavy Atom Count: 12
• Complexity: 199

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tetrafluorosuccinic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): XiC
• Hazard Codes: Xi,C
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(=O)(C(C(C(=O)O)(F)F)(F)F)O

Technology Process of Tetrafluorosuccinic acid

There total 23 articles about Tetrafluorosuccinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.9%

1,3,3,4,4-pentafluorocyclobut-1-ene (374-31-2) → tetrafluorosuccinic acid (377-38-8)

Guidance literature:

With potassium permanganate; tetrabutyl phosphonium bromide; In dichloromethane; water;

Reference yield: 84.1%

1,2-dichloro-3,3,4,4-tetrafluorocyclobutene (377-93-5) → tetrafluorosuccinic acid (377-38-8)

Guidance literature:

With potassium permanganate; tetrabutylammomium bromide; In water; acetone; at 10 - 20 ℃; for 0.5h;

Reference yield: 83.6%

perfluorosuccinic anhydride (699-30-9) + tetrafluorosuccinyl chloride (356-15-0) → tetrafluorosuccinic acid (377-38-8)

Guidance literature:

With water; at 30 ℃; for 2.5h; Reagent/catalyst;

upstream raw materials:

Difluoroacetic acid

1,2-dichloro-3,3,4,4-tetrafluorocyclobutene

hexafluorocyclobut-1-ene

1-methoxy-2,3,3,4,4-pentafluorocyclobut-1-ene

Downstream raw materials:

diethyl tetrafluorosuccinate

perfluorosuccinic anhydride

tetrafluorosuccinyl chloride

perfluorosuccinic difluoride

Refernces

• 1、 -. "Preparation method of fluorine-containing dicarboxylic acid". Paragraph 0045. . Retrieved 2020/07/12.
• 2、 -. "Preparation method of fluorine-containing carboxylic acid". Paragraph 0033; 0035-0036. . Retrieved 2020/07/12.