17-Phenyl-18,19,20-trinor-pge2 1,15-lactone

Base Information

• Chemical Name: 17-Phenyl-18,19,20-trinor-pge2 1,15-lactone
• CAS No.: 62411-16-9
• Molecular Formula: C₂₃H₃₀O₄
• Molecular Weight: 370.489
• Mol file: 62411-16-9.mol

Synonyms:17-Phenyl-18,19,20-trinor-pge2 1,15-lactone;17-Phenyl-18,19,20-trinor-prostaglandin E2 1,15-lactone;3H-Cyclopent(e)oxacyclotridecin-5,12-dione, 6,7,8,11,11a,13,14,14a-octahydro-14-hydroxy-3-(2-phenylethyl)-, (3S-(1E,3R*,8Z,11aS*,14S*,14aS*))-;62411-16-9;LS-58415

Chemical Property of 17-Phenyl-18,19,20-trinor-pge2 1,15-lactone

Chemical Property:

• Vapor Pressure: 1.87E-14mmHg at 25°C
• Boiling Point: 583.4°C at 760 mmHg
• Flash Point: 201.8°C
• Density: 1.114g/cm³
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 368.19875937
• Heavy Atom Count: 27
• Complexity: 559

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC=CCC2C(C=CC(OC(=O)C1)CCC3=CC=CC=C3)C(CC2=O)O
• Isomeric SMILES: C1C/C=C\C[C@@H]2[C@@H](/C=C\[C@@H](OC(=O)C1)CCC3=CC=CC=C3)[C@@H](CC2=O)O

Technology Process of 17-Phenyl-18,19,20-trinor-pge2 1,15-lactone

There total 2 articles about 17-Phenyl-18,19,20-trinor-pge2 1,15-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

17-phenyl-18,19,20-trinor-PGE2 (55122-62-8,41640-36-2) → 17-phenyl-18,19,20-trinor-PGE2 1,15-lactone (62411-16-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Ph₃P / xylene / 18 h / Ambient temperature

2: xylene / 2.5 h / Heating

With triphenylphosphine; In xylene;

DOI:10.1021/jm00362a001

Reference yield:

7-[(1R,2R,3R)-3-Hydroxy-2-((E)-(S)-3-hydroxy-5-phenyl-pent-1-enyl)-5-oxo-cyclopentyl]-heptanethioic acid S-pyridin-2-yl ester → 17-phenyl-18,19,20-trinor-PGE2 1,15-lactone (62411-16-9)

Guidance literature:

In xylene; for 2.5h; Yield given; Heating;

DOI:10.1021/jm00362a001

upstream raw materials:

17-phenyl-18,19,20-trinor-PGE₂

Refernces