3-hydroxycarbazole

Base Information

• Chemical Name: 3-hydroxycarbazole
• CAS No.: 7384-07-8
• Molecular Formula: C12H9 N O
• Molecular Weight: 183.21
• Hs Code.: 2933990090
• Mol file: 7384-07-8.mol

Synonyms:Carbazol-3-ol(6CI,7CI,8CI); 3-Hydroxycarbazole

Chemical Property of 3-hydroxycarbazole

Chemical Property:

• Vapor Pressure: 4.78E-08mmHg at 25°C
• Melting Point: 256-257 °C
• Boiling Point: 431.4°C at 760 mmHg
• PKA: 9.98±0.30(Predicted)
• Flash Point: 214.7°C
• PSA: 36.02000
• Density: 1.362g/cm³
• LogP: 3.02670
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Dichloromethane, DMSO (Slightly), Ethyl Acetate, Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

9H-Carbazol-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Carbazol-3-ol is a metabolite of N-methylcarbazole in mammals. Mutagenic.

Technology Process of 3-hydroxycarbazole

There total 30 articles about 3-hydroxycarbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-methoxycarbazole (18992-85-3) → 3-Hydroxycarbazol (7384-07-8)

Guidance literature:

With hydrogen bromide; In water; acetic acid; Heating;

DOI:10.1002/1099-0690(200206)2002:12<1952::AID-EJOC1952>3.0.CO;2-L

Reference yield: 95.0%

ethyl 3-hydroxy-9H-carbazole-9-carboxylate (361434-23-3) → 3-Hydroxycarbazol (7384-07-8)

Guidance literature:

With potassium hydroxide; In methanol; Heating;

DOI:10.1016/S0040-4039(01)00854-1

Reference yield: 72.0%

1,2,3,4-tetrahydro-6-hydroxycarbazole (13314-76-6) → 3-Hydroxycarbazol (7384-07-8)

Guidance literature:

With copper(II) choride dihydrate; In dimethyl sulfoxide; at 100 ℃; for 7h;

DOI:10.1016/j.tetlet.2018.01.061

upstream raw materials:

3-methoxycarbazole

3-bromo-9H-carbazole

1,2,3,4-tetrahydro-6-hydroxycarbazole

3-ethoxy-carbazole

Downstream raw materials:

1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonic acid 9-(toluene-4-sulfonyl)-9H-carbazol-3-yl ester

Refernces

• 1、 Kasemthaveechok, Sitthichok,Abella, Laura,Jean, Marion,Cordier, Marie,Roisnel, Thierry,Vanthuyne, Nicolas,Guizouarn, Thierry,Cador, Olivier,Autschbach, Jochen,Crassous, Jeanne,Favereau, Ludovic. "Axially and Helically Chiral Cationic Radical Bicarbazoles: SOMO-HOMO Level Inversion and Chirality Impact on the Stability of Mono- And Diradical Cations". . p. 20409 - 20418. Retrieved 2020.
• 2、 Sumsalee, Patthira,Abella, Laura,Kasemthaveechok, Sitthichok,Vanthuyne, Nicolas,Cordier, Marie,Pieters, Grégory,Autschbach, Jochen,Crassous, Jeanne,Favereau, Ludovic. "Luminescent Chiral Exciplexes with Sky-Blue and Green Circularly Polarized-Thermally Activated Delayed Fluorescence". supporting information. p. 16505 - 16511. Retrieved 2021/11/01.