D-Valine, 3-methyl-, methyl ester

Base Information

• Chemical Name: D-Valine, 3-methyl-, methyl ester
• CAS No.: 112245-08-6
• Molecular Formula: C7H15NO2
• Molecular Weight: 145.202
• Mol file: 112245-08-6.mol

Synonyms:3-Methyl-d-valine methyl este;

Chemical Property of D-Valine, 3-methyl-, methyl ester

Chemical Property:

• PSA: 52.32000
• LogP: 1.23310

Purity/Quality:

99% ^*data from raw suppliers

3-Methyl-d-valinemethylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Use Description: D-Valine, 3-methyl-, methyl ester is a chemical compound with applications in various fields. In the pharmaceutical industry, it can serve as a key intermediate in the synthesis of pharmaceutical compounds, particularly those used in the development of medications targeting bacterial infections and neurological disorders. Its role is pivotal in the structural modification of molecules, allowing for the creation of novel drug candidates with potential therapeutic properties. Additionally, in academic research and organic chemistry, this compound can be employed as a building block for the synthesis of complex organic molecules, facilitating studies in chemical synthesis and chemical biology. Its versatile applications highlight its significance in drug discovery, academic research, and the advancement of chemical science, ultimately contributing to the improvement of healthcare and scientific knowledge.

Technology Process of D-Valine, 3-methyl-, methyl ester

There total 2 articles about D-Valine, 3-methyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ methyl (R)-2-amino-3,3-dimethylbutanoate (112245-08-6)

Guidance literature:

With thionyl chloride; In methanol; at 0 ℃; for 2h; Reflux;

In methanol; at 20 ℃; for 0.5h;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + Trimethylpyruvic acid oxime (62965-34-8) → methyl (R)-2-amino-3,3-dimethylbutanoate (112245-08-6)

Guidance literature:

Multistep reaction; (i) Et₂O, (ii) Al-Hg, H₂O, (iii) (racemate resolution using dibenzoyl-(S)-tartaric acid);

Reference yield:

methyl (R)-2-amino-3,3-dimethylbutanoate (112245-08-6) → D-tert-leucine (26782-71-8)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

diazomethane

Trimethylpyruvic acid oxime

Downstream raw materials:

D-tert-leucine

(2R)-2-amino-3,3-dimethylbutan-1-ol

(R)-2-amino-3,3-dimethyl-1,1-diphenylbutan-1-ol

(R)-4-(tert-butyl)-5,5-diphenyloxazolidin-2-one

Refernces