Paromomycin sulfate

Base Information

• Chemical Name: Paromomycin sulfate
• CAS No.: 1263-89-4
• Deprecated CAS: 11048-06-9,1405-13-6,14963-45-2,51981-74-9,42438-81-3,52279-67-1
• Molecular Formula: C23H45N5O14•H2O4S
• Molecular Weight: 713.81
• Hs Code.: 2941901010
• European Community (EC) Number: 230-575-5,215-031-7
• UNII: 845NU6GJPS
• DSSTox Substance ID: DTXSID601335979
• Wikidata: Q27269495
• NCI Thesaurus Code: C47652
• RXCUI: 66912
• ChEMBL ID: CHEMBL2206196
• Mol file: 1263-89-4.mol

Synonyms:Aminosidine;beta-D-Glucopyranosyl-Isomer Paromomycin;Catenulin;Estomycin;Gabbromycin;Humatin;Hydroxymycin;Neomycin E;Paramomycin;Paromomycin;Paromomycin I;Paromomycin Phosphate;Paromomycin Sulfate;Paromomycin Sulfate (1:1);Paromomycin Sulfate (2:5);Paromomycin, beta D Glucopyranosyl Isomer;Paromomycin, beta-D-Glucopyranosyl-Isomer

Chemical Property of Paromomycin sulfate

Chemical Property:

• Appearance/Colour: powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: >200oC
• Boiling Point: 939.8 °C at 760 mmHg
• Flash Point: 522.2 °C
• PSA: 430.30000
• LogP: -4.93220
• Storage Temp.: 0-6°C
• Solubility.: H2O: 50 mg/mL store stock solution at 2-8°C. Stable
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 15
• Hydrogen Bond Acceptor Count: 23
• Rotatable Bond Count: 9
• Exact Mass: 713.26368084
• Heavy Atom Count: 47
• Complexity: 952

Purity/Quality:

99%MIN ^*data from raw suppliers

Paromomycin sulfate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 23/24/25-36/38-39/23/24/25-61-36/37/38
• Safety Statements: 26-36/37-45-38-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
• Isomeric SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
• Recent ClinicalTrials: A Double-Blind, Placebo-Controlled Trial of Paromomycin for Treatment of Cryptosporidiosis in Patients With Advanced HIV Disease and CD4 Counts Under 150 Cells/mm3
• Recent EU Clinical Trials: Controlled, randomized trial, comparing the efficacy of paromomicin and
• Uses: antibacterial, antiamebic polymeric nonionic detergent PAROMOMYCIN SULFATE is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed addit ive in turkey poults experimentally infected with Histomonas meleagridis.
• Clinical Use: The isolation of paromomycin (Humatin) was reported in1956 from a fermentation with a Streptomyces sp. (PD04998), a strain said to resemble S. rimosus very closely.The parent organism had been obtained from soil samplescollected in Colombia. Paromomycin, however, moreclosely resembles neomycin and streptomycin in antibioticactivity than it does oxytetracycline, the antibiotic obtainedfrom S. rimosus.Paromomycin has broad-spectrum antibacterial activityand has been used for the treatment of GI infections causedby Salmonella and Shigella spp., and enteropathogenic E.coli. Currently, however, its use is restricted largely to thetreatment of intestinal amebiasis. Paromomycin is soluble inwater and stable to heat over a wide pH range.