4,6-Dichloro-3-methoxypyridazine

Base Information

• Chemical Name: 4,6-Dichloro-3-methoxypyridazine
• CAS No.: 112342-58-2
• Molecular Formula: C5H4Cl2N2O
• Molecular Weight: 179.00400
• DSSTox Substance ID: DTXSID50548144
• Wikidata: Q82426757
• Mol file: 112342-58-2.mol

Synonyms:4,6-Dichloro-3-methoxypyridazine;112342-58-2;Pyridazine, 4,6-dichloro-3-methoxy-;DTXSID50548144;A902597

Chemical Property of 4,6-Dichloro-3-methoxypyridazine

Chemical Property:

• Melting Point: 80-81 °C(Solv: cyclohexane (110-82-7))
• Boiling Point: 317.3±37.0 °C(Predicted)
• PKA: -1.15±0.10(Predicted)
• PSA: 35.01000
• Density: 1.446±0.06 g/cm3(Predicted)
• LogP: 1.79200
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 177.9700681
• Heavy Atom Count: 10
• Complexity: 114

Purity/Quality:

99% ^*data from raw suppliers

4,6-DICHLORO-3-METHOXYPYRIDAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=NN=C(C=C1Cl)Cl

Technology Process of 4,6-Dichloro-3-methoxypyridazine

There total 1 articles about 4,6-Dichloro-3-methoxypyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-Chloro-3-methoxy-1H-pyridazin-4-one (112342-60-6) → 4,6-dichloro-3-methoxypyridazine (112342-58-2)

Guidance literature:

With trichlorophosphate; at 80 ℃;

Reference yield: 91.0%

methanol (67-56-1) + 4,6-dichloro-3-methoxypyridazine (112342-58-2) → 6-chloro-3,4-dimethoxypyridazine (2096-21-1)

Guidance literature:

With sodium methylate; for 1h; Heating;

Reference yield: 68.0%

4-methylphenylboronic acid (5720-05-8) + 4,6-dichloro-3-methoxypyridazine (112342-58-2) → C12H11ClN2O (1448295-37-1) + C12H11ClN2O (1448295-49-5) + C19H18N2O

Guidance literature:

With potassium fluoride; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; palladium diacetate; In water; toluene; at 70 ℃; for 20h; Inert atmosphere;

DOI:10.1021/jo401096u

upstream raw materials:

6-Chloro-3-methoxy-1H-pyridazin-4-one

Downstream raw materials:

6-chloro-3,4-dimethoxypyridazine

C₁₂H₁₁ClN₂O

C₁₂H₁₁ClN₂O

C₁₂H₁₁ClN₂O

Refernces