Technology Process of Cyclorphan
There total 10 articles about Cyclorphan which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Et3N / CH2Cl2 / 14 h / Heating
2: LiAlH4 / tetrahydrofuran / 20 °C
With
lithium aluminium tetrahydride; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm9903343
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 99 percent / diethyl ether; methanol / 20 °C
2.1: NaHCO3; 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 48 h / Heating
2.2: 90 percent / MeOH / 3 h / Heating
3.1: HBr; AcOH
4.1: Et3N / CH2Cl2 / 14 h / Heating
5.1: LiAlH4 / tetrahydrofuran / 20 °C
With
lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; hydrogen bromide; sodium hydrogencarbonate; acetic acid; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm9903343