Technology Process of 2-Thiopheneacetic acid, a-[[(2-nitrophenyl)thio]amino]-,
1,3,3-trimethylbicyclo[2.2.1]hept-2-yl ester
There total 3 articles about 2-Thiopheneacetic acid, a-[[(2-nitrophenyl)thio]amino]-,
1,3,3-trimethylbicyclo[2.2.1]hept-2-yl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; dicyclohexyl-carbodiimide;
In
tetrahydrofuran;
1.) -65 deg C, 20 min, 2.) from -65 deg C to -23 deg C, 3 h, 3.) RT, overnight;
DOI:10.1021/jm00168a022
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 64 percent / 5 N NaOH / dioxane / 2 h
2: 38 percent / dicyclohexylcarbodiimide (DCC), 4-(dimethylamino)pyridine (DMAP) / tetrahydrofuran / 1.) -65 deg C, 20 min, 2.) from -65 deg C to -23 deg C, 3 h, 3.) RT, overnight
With
dmap; sodium hydroxide; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm00168a022
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 64 percent / 5 N NaOH / dioxane / 2 h
2: 38 percent / dicyclohexylcarbodiimide (DCC), 4-(dimethylamino)pyridine (DMAP) / tetrahydrofuran / 1.) -65 deg C, 20 min, 2.) from -65 deg C to -23 deg C, 3 h, 3.) RT, overnight
With
dmap; sodium hydroxide; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm00168a022
