2-Methyl-6-nitrobenzotrifluoride

Base Information

• Chemical Name: 2-Methyl-6-nitrobenzotrifluoride
• CAS No.: 112641-21-1
• Molecular Formula: C8H6F3NO2
• Molecular Weight: 205.13400
• Hs Code.: 2904909090
• Mol file: 112641-21-1.mol

Synonyms:1-methyl-3-nitro-1H-pyrazole-4-carboxylic acid piperidin-1-ylmethylamide;1H-Pyrazole-4-carboxamide,1-methyl-3-nitro-N-(1-piperidinylmethyl);1-methyl-3-nitro-2-(trifluoromethyl)benzene;

Chemical Property of 2-Methyl-6-nitrobenzotrifluoride

Chemical Property:

• Boiling Point: 234.7±40.0 °C(Predicted)
• PSA: 45.82000
• Density: 1.357±0.06 g/cm3(Predicted)
• LogP: 3.44520

Purity/Quality:

98%min ^*data from raw suppliers

2-Methyl-6-nitrobenzotrifluoride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-6-nitrobenzotrifluoride

There total 2 articles about 2-Methyl-6-nitrobenzotrifluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

C13H20N4O2 (1448037-99-7) + (trifluoromethyl)trimethylsilane (81290-20-2) → 1-methyl-3-nitro-2-(trifluoromethyl)benzene (112641-21-1)

Guidance literature:

C₁₃H₂₀N₄O₂; With methyl iodide; at 110 ℃; Inert atmosphere;

(trifluoromethyl)trimethylsilane; With potassium fluoride; copper(l) iodide; In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 16h; Inert atmosphere;

DOI:10.1002/adsc.201201040

Reference yield:

iodotrifluoromethane (2314-97-8,263005-66-9) + 2-iodo-3-nitrotoluene (6277-17-4) → 1-methyl-3-nitro-2-(trifluoromethyl)benzene (112641-21-1)

Guidance literature:

With copper; In N-methyl-acetamide;

Reference yield:

1-methyl-3-nitro-2-(trifluoromethyl)benzene (112641-21-1) → 1-(Dibromomethyl)-3-nitro-2-(trifluoromethyl)benzene (112662-21-2)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane;

upstream raw materials:

iodotrifluoromethane

2-iodo-3-nitrotoluene

C₁₃H₂₀N₄O₂

(trifluoromethyl)trimethylsilane

Downstream raw materials:

1-(Dibromomethyl)-3-nitro-2-(trifluoromethyl)benzene

Refernces

• 1、 -. "Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof". . . Retrieved 2008/06/13.