Bryostatin-1

Base Information Edit

Chemical Name:Bryostatin-1
CAS No.:83314-01-6
Molecular Formula:C47H68 O17
Molecular Weight:905.03
Hs Code.:2932990090
NCI Thesaurus Code:C1026
Wikidata:Q105165592
Mol file:83314-01-6.mol

Synonyms:bryostatin 1

Suppliers and Price of Bryostatin-1

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Bryostatin 1
10ug
$ 432.00

Tocris
Bryostatin 1 ≥98%(HPLC)
10U
$ 187.00

Sigma-Aldrich
Bryostatin 1 ≥99%, solid
10ug
$ 183.00

Sigma-Aldrich
Bryostatin 1 A macrocyclic lactone with antitumor properties.
10ug
$ 183.00

Sigma-Aldrich
Bryostatin 1 ≥99%, solid
10 μg
$ 190.00

ChemScene
Bryostatin 1
10ug
$ 480.00

ApexBio Technology
Bryostatin 1
10ug
$ 266.00

American Custom Chemicals Corporation
BRYOSTATIN 1 95.00%
25μG
$ 945.01

American Custom Chemicals Corporation
BRYOSTATIN 1 95.00%
10μG
$ 720.48

Total 20 raw suppliers

Chemical Property of Bryostatin-1 Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:230-235°
Refractive Index:1.5940 (estimate)
Boiling Point:954.7°C at 760 mmHg
Flash Point:270°C
PSA：240.11000
Density:1.27g/cm³
LogP:4.27990
Storage Temp.:−20°C
Solubility.:DMSO: soluble
XLogP3:4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:17
Rotatable Bond Count:13
Exact Mass:904.44565070
Heavy Atom Count:64
Complexity:1830

Purity/Quality:

96% 1H NMR ^*data from raw suppliers

Bryostatin 1 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 68
Safety Statements: 22-24/25-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCC=CC=CC(=O)OC1C(=CC(=O)OC)CC2CC(OC(=O)CC(CC3CC(C(C(O3)(CC4CC(=CC(=O)OC)CC(O4)C=CC(C1(O2)O)(C)C)O)(C)C)OC(=O)C)O)C(C)O
Isomeric SMILES:CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)/C[C@H]2C[C@@H](OC(=O)C[C@@H](C[C@@H]3C[C@@H](C([C@@](O3)(C[C@@H]4C/C(=C/C(=O)OC)/CC(O4)/C=C/C([C@@]1(O2)O)(C)C)O)(C)C)OC(=O)C)O)[C@@H](C)O
Recent ClinicalTrials:Safety of Bryostatin in Patients With MS
Uses Bryostatin 1 has been used to study its effects on spontaneous Crohn′s disease (CD) like colitis in?mice. It has also been used to study its effects as an anthelmintic drug on adult Syphacia muris infection in rats.

Technology Process of Bryostatin-1

There total 14 articles about Bryostatin-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 136205-46-4
C₅₃H₈₂O₁₇Si

: 83314-01-6,142451-66-9
bryostatin 1

Guidance literature:: With hydrogen fluoride; In acetonitrile; at 0 - 5 ℃; for 1.5h;
DOI:10.1139/v91-126

Reference yield: 80.0%

: C₇₀H₁₀₂O₁₇Si₂

: 83314-01-6
bryostatin 1

Guidance literature:: C₇₀H₁₀₂O₁₇Si₂; With pyridine; pyridine hydrogenfluoride; In tetrahydrofuran; at 40 ℃;

In water; at 40 ℃;
DOI:10.1126/science.aan7969