2-(Methylamino)phenol

Base Information

• Chemical Name: 2-(Methylamino)phenol
• CAS No.: 611-24-5
• Molecular Formula: C7H9NO
• Molecular Weight: 123.155
• Hs Code.: 29222900
• European Community (EC) Number: 210-263-5
• NSC Number: 245030
• UNII: LDM886MY3T
• DSSTox Substance ID: DTXSID60209976
• Nikkaji Number: J96.115I
• Wikidata: Q83084502
• ChEMBL ID: CHEMBL281223
• Mol file: 611-24-5.mol

Synonyms:2-(Methylamino)phenol;611-24-5;2-Methylaminophenol;o-(Methylamino)phenol;2-methylamino-phenol;Phenol, (methylamino)-;N-Methyl-2-hydroxyaniline;Phenol, o-(methylamino)-;Phenol, 2-(methylamino)-;2-Hydroxy-N-methylaniline;LDM886MY3T;EINECS 210-263-5;MFCD00462180;NSC-245030;N-Methyl-2-aminophenol;NSC245030;N(C)c1ccccc1O;2-(n-methylamino)phenol;N-Methyl-o-hydroxyaniline;2-(N-methylamino)-phenol;UNII-LDM886MY3T;SCHEMBL457878;CHEMBL281223;DTXSID60209976;2-(Methylamino)phenol, >=97%;AMY29124;CS-B1556;STK011284;AKOS006223481;NSC 245030;PS-5336;SY110000;FT-0691794;(R)-tetrahydro-2H-pyran-3-amine?hydrochloride;EN300-176677;O10530;A847416

Chemical Property of 2-(Methylamino)phenol

Chemical Property:

• Appearance/Colour: brown very fine crystalline powder
• Vapor Pressure: 0.0384mmHg at 25°C
• Melting Point: 85-88 °C
• Refractive Index: 1.5730 (589.3 nm 33℃)
• Boiling Point: 232.6 °C at 760 mmHg
• PKA: 10.62±0.10(Predicted)
• Flash Point: 122.1 °C
• PSA: 32.26000
• Density: 1.147g/cm³
• LogP: 1.50690
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 123.068413911
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Methylamino)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CNC1=CC=CC=C1O

Technology Process of 2-(Methylamino)phenol

There total 46 articles about 2-(Methylamino)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzoxazole (273-53-0,29791-96-6) → o-(N-methylamino)phenol (611-24-5)

Guidance literature:

With sodium tetrahydroborate; acetic acid; In tetrahydrofuran; for 18h;

DOI:10.3987/COM-93-6523

Reference yield: 95.0%

3-methylbenzo[d]oxazol-2(3H)-one (21892-80-8) → o-(N-methylamino)phenol (611-24-5)

Guidance literature:

With ammonium bromide; ethylenediamine; at 70 ℃; for 2h; Microwave irradiation;

Reference yield: 74.0%

2-sulfanyl-1,3-benzoxazole (2382-96-9,118090-08-7) → o-(N-methylamino)phenol (611-24-5)

Guidance literature:

With tetrahydrofuran; lithium aluminium tetrahydride; for 3h; Heating;

DOI:10.1002/hlca.19830660126

upstream raw materials:

3-methylbenzo[d]oxazol-2(3H)-one

2-(N-acetyl-N-methylamino)phenol

N-methyl-N-(2-methoxyphenyl)-4-methylbenzenesulfonamide

2-methoxy-N-methylaniline

Downstream raw materials:

2-(N-methylacetamido)phenyl acetate

2-(N-methyl-2,4-dinitro-anilino)-phenol

2-(2,4-dinitro-phenoxy)-N-methyl-aniline

3-methylbenzoxazole-2-thione

Refernces

• 1、 Noshita, Megumi,Shimizu, Yuhei,Morimoto, Hiroyuki,Ohshima, Takashi. "Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas". supporting information. p. 6062 - 6065. Retrieved 2016/12/09.
• 2、 -. "PRODUCTION METHOD FOR COMPOUND COMPRISING AMINO GROUP AND/OR HYDROXYL GROUP". Paragraph 0095. . Retrieved 2015/01/18.